Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …
Autophagy in major human diseases
Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
Selective autophagy receptor p62/SQSTM1, a pivotal player in stress and aging
AV Kumar, J Mills, LR Lapierre - Frontiers in cell and developmental …, 2022 - frontiersin.org
Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads
to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by …
to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by …
Nrf2 and ferroptosis: a new research direction for neurodegenerative diseases
X Song, D Long - Frontiers in neuroscience, 2020 - frontiersin.org
Ferroptosis is a kind of regulated cell death (RCD) caused by the redox state disorder of
intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which …
intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which …
Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets
F Shu, H ** genetics of amyotrophic lateral sclerosis and frontotemporal dementia
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two diseases
that form a broad neurodegenerative continuum. Considerable effort has been made to …
that form a broad neurodegenerative continuum. Considerable effort has been made to …
Novel target for treating Alzheimer's Diseases: Crosstalk between the Nrf2 pathway and autophagy
W Zhang, C Feng, H Jiang - Ageing research reviews, 2021 - Elsevier
Abstract In mammals, the Keap1-Nrf2-ARE pathway (henceforth,“the Nrf2 pathway”) and
autophagy are major intracellular defence systems that combat oxidative damage and …
autophagy are major intracellular defence systems that combat oxidative damage and …
Nrf2 signaling pathway in cisplatin chemotherapy: Potential involvement in organ protection and chemoresistance
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a vital transcription factor and its induction
is of significant importance for protecting against oxidative damage. Increased levels of …
is of significant importance for protecting against oxidative damage. Increased levels of …
[HTML][HTML] The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via …
ER Gallagher, ELF Holzbaur - Cell reports, 2023 - cell.com
In response to lysosomal damage, cells engage several quality-control mechanisms,
including the selective isolation and degradation of damaged lysosomes by lysophagy …
including the selective isolation and degradation of damaged lysosomes by lysophagy …
Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules
C Yang, Z Wang, Y Kang, Q Yi, T Wang, Y Bai, Y Liu - Autophagy, 2023 - Taylor & Francis
Eukaryotic stress granules (SGs) are highly dynamic assemblies of untranslated mRNAs
and proteins that form through liquid-liquid phase separation (LLPS) under cellular stress …
and proteins that form through liquid-liquid phase separation (LLPS) under cellular stress …