Background Multimorbidity, the coexistence of multiple chronic diseases in an individual, is
highly prevalent and challenging for healthcare systems. However, its risk factors remain …

Obesity and chronic kidney disease are two ongoing progressive clinical pandemics of
major public health and clinical care significance. Because of their growing prevalence …

Background The association of changes in waist circumference (WC), waist-to-height ratio
(WHtR) and weight-adjusted-waist index (WWI) with subsequent risk of multimorbidity …

Multimorbidity—the coexistence of at least two chronic health conditions within the same
individual—is an important global health challenge. In high‐income countries (HICs) …

Background Ageing hallmarks, characterising features of cellular ageing, have a role in the
pathophysiology of many age-related diseases. We examined whether obesity is associated …

Glucagon-like peptide-1 (GLP-1), secreted by intestinal L-cells, plays a pivotal role in the
modulation of β-cell insulin secretion in a glucose-dependent manner, concurrently …

Background Patients with multiple long-term conditions requires understanding the existing
care models to address their complex and multifaceted health needs. However, current …

As the most common psychiatric symptom, depression represents a subject of high interest
for the medical community. Background/Objectives: International guidelines consider …

Objective To verify the dose-response relationship between body mass index (BMI) and
multimorbidity risk. Methods PubMed, CINAHL, and Embase were systematically studied …

Objective This study aimed to investigate the association of whole body/regional fat mass
(FM) with cardiometabolic disease (CMD) trajectory. Methods We conducted a prospective …