Benzimidazole, the benzo derivative of imidazole, is a class of bicyclic aromatic organic
compound consisting of six‐membered benzene ring fused to five‐membered imidazole at 4 …

Cancer is the second leading cause of death globally, with 9.6 million deaths yearly. As a life‐
threatening disease, it necessitates the emergence of new therapies. Resistance to current …

Breast cancer is the most frequent female cancer and second cause of cancer-related
deaths among women around the world. Two thirds of breast cancer patients have hormone …

The pandemic caused by COVID-19 hinders everything on earth, including physical and
mental health, daily life and the global economy. Currently, there are no defined drugs and …

A receptor-based pharmacophore model describing the binding features required for the
multi-kinase inhibition of the target kinases (VEGFR-2, FGFR-1, and BRAF) were …

Cancer, characterized by a deregulation of the cell cycle which mainly results in a
progressive loss of cellular differentiation and uncontrolled cellular growth, remains a …

In this study, we designed, synthesized, and evaluated a series of 1, 2, 4-triazole
benzimidazoles for their cytotoxic effects against the A549, C6, and NIH3T3 cell lines …

The therapeutic potential of the benzimidazole nucleus has been recognized since 1944,
and it is an important heterocycle system due to its presence in a wide range of bioactive …

In this study, a series of novel 1, 3, 4-oxadiazole-benzimidazole derivatives were designed
and synthesized. Their cytotoxic activities against five cancer cell lines, including A549, MCF …

Oxadiazoles and their derivatives with thioether functionalities represent a new and exciting
class of physiologically active heterocyclic compounds. Several molecules with these …