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Subcellular organization: a critical feature of bacterial cell replication
Spatial organization is a hallmark of all living systems. Even bacteria, the smallest forms of
cellular life, display defined shapes and complex internal organization, showcasing a highly …
cellular life, display defined shapes and complex internal organization, showcasing a highly …
Coupled transcription-translation in prokaryotes: an old couple with new surprises
Coupled transcription-translation (CTT) is a hallmark of prokaryotic gene expression. CTT
occurs when ribosomes associate with and initiate translation of mRNAs whose transcription …
occurs when ribosomes associate with and initiate translation of mRNAs whose transcription …
Molecular dynamics simulation of an entire cell
The ultimate microscope, directed at a cell, would reveal the dynamics of all the cell's
components with atomic resolution. In contrast to their real-world counterparts …
components with atomic resolution. In contrast to their real-world counterparts …
Superresolution imaging of ribosomes and RNA polymerase in live Escherichia coli cells
Quantitative spatial distributions of ribosomes (S2‐YFP) and RNA polymerase (RNAP; β′‐
yGFP) in live Escherichia coli are measured by superresolution fluorescence microscopy. In …
yGFP) in live Escherichia coli are measured by superresolution fluorescence microscopy. In …
Live-cell superresolution microscopy reveals the organization of RNA polymerase in the bacterial nucleoid
Despite the fundamental importance of transcription, a comprehensive analysis of RNA
polymerase (RNAP) behavior and its role in the nucleoid organization in vivo is lacking …
polymerase (RNAP) behavior and its role in the nucleoid organization in vivo is lacking …
Single-particle tracking reveals that free ribosomal subunits are not excluded from the Escherichia coli nucleoid
Biochemical and genetic data show that ribosomes closely follow RNA polymerases that are
transcribing protein-coding genes in bacteria. At the same time, electron and fluorescence …
transcribing protein-coding genes in bacteria. At the same time, electron and fluorescence …
Interconnecting solvent quality, transcription, and chromosome folding in Escherichia coli
All cells fold their genomes, including bacterial cells, where the chromosome is compacted
into a domain-organized meshwork called the nucleoid. How compaction and domain …
into a domain-organized meshwork called the nucleoid. How compaction and domain …
The spatial biology of transcription and translation in rapidly growing Escherichia coli
Single-molecule fluorescence provides high resolution spatial distributions of ribosomes
and RNA polymerase (RNAP) in live, rapidly growing Escherichia coli. Ribosomes are more …
and RNA polymerase (RNAP) in live, rapidly growing Escherichia coli. Ribosomes are more …
Membrane-localized expression, production and assembly of Vibrio parahaemolyticus T3SS2 provides evidence for transertion
It has been proposed that bacterial membrane proteins may be synthesized and inserted
into the membrane by a process known as transertion, which involves membrane …
into the membrane by a process known as transertion, which involves membrane …
Localization of Protein Aggregation in Escherichia coli Is Governed by Diffusion and Nucleoid Macromolecular Crowding Effect
AS Coquel, JP Jacob, M Primet… - PLoS computational …, 2013 - journals.plos.org
Aggregates of misfolded proteins are a hallmark of many age-related diseases. Recently,
they have been linked to aging of Escherichia coli (E. coli) where protein aggregates …
they have been linked to aging of Escherichia coli (E. coli) where protein aggregates …