Targeting the JAK/STAT signaling pathway using phytocompounds for cancer prevention and therapy

S Bose, S Banerjee, A Mondal, U Chakraborty… - Cells, 2020 - mdpi.com
Cancer is a prevalent cause of mortality around the world. Aberrated activation of Janus
kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway …

Biochanin A: A novel bioactive multifunctional compound from nature

A Sarfraz, M Javeed, MA Shah, G Hussain… - Science of the Total …, 2020 - Elsevier
Natural products (NPs) will continue to serve humans as matchless source of novel drug
leads and an inspiration for the synthesis of non-natural drugs. As our scientific …

Targeting apoptosis pathways in cancer and perspectives with natural compounds from mother nature

FM Millimouno, J Dong, L Yang, J Li, X Li - Cancer prevention research, 2014 - AACR
Although the incidences are increasing day after day, scientists and researchers taken
individually or by research group are trying to fight against cancer by several ways and also …

Applications of sesquiterpene lactones: a review of some potential success cases

L Moujir, O Callies, PMC Sousa, F Sharopov… - Applied Sciences, 2020 - mdpi.com
Sesquiterpene lactones, a vast range of terpenoids isolated from Asteraceae species,
exhibit a broad spectrum of biological effects and several of them are already commercially …

Nanoformulated codelivery of quercetin and alantolactone promotes an antitumor response through synergistic immunogenic cell death for microsatellite-stable …

J Zhang, L Shen, X Li, W Song, Y Liu, L Huang - Acs Nano, 2019 - ACS Publications
Microsatellite-stable colorectal cancer (CRC) is known to be resistant to immunotherapy.
The combination of quercetin (Q) and alantolactone (A) was found to induce synergistic …

Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products

MM Rahman, MT Sarker, MA Alam Tumpa… - Frontiers in …, 2022 - frontiersin.org
Cancer is commonly thought to be the product of irregular cell division. According to the
World Health Organization (WHO), cancer is the major cause of death globally. Nature offers …

[HTML][HTML] Curcumol: from plant roots to cancer roots

W Wei, A Rasul, A Sadiqa, I Sarfraz… - … Journal of Biological …, 2019 - ncbi.nlm.nih.gov
Natural products, an infinite treasure of bioactive scaffolds, have provided an excellent
reservoir for the discovery of drugs since millennium. These naturally occurring, biologically …

Back to the roots—an overview of the chemical composition and bioactivity of selected root-essential oils

K Lunz, I Stappen - Molecules, 2021 - mdpi.com
Since ancient times, plant roots have been widely used in traditional medicine for treating
various ailments and diseases due to their beneficial effects. A large number of studies have …

Natural products against cancer angiogenesis

EB Khalid, ELMELK Ayman, H Rahman, G Abdelkarim… - Tumor Biology, 2016 - Springer
The process of angiogenesis is quite well-known nowadays. Some medicines and extracts
affecting this process are already used routinely in supporting the conventional treatment of …

Sesquiterpene lactones as promising candidates for cancer therapy: Focus on pancreatic cancer

LC Laurella, NT Mirakian, MN Garcia, DH Grasso… - Molecules, 2022 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease which confers to
patients a poor prognosis at short term. PDAC is the fourth leading cause of death among …