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Gut-liver axis: Pathophysiological concepts and clinical implications
Bidirectional crosstalk along the gut-liver axis controls gastrointestinal health and disease
and exploits environmental and host mediators. Nutrients, microbial antigens, metabolites …
and exploits environmental and host mediators. Nutrients, microbial antigens, metabolites …
Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets
Bile acids, once considered mere dietary surfactants, now emerge as critical modulators of
macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro …
macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro …
Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis
Non-alcoholic fatty liver disease (NAFLD) is regarded as a pandemic that affects about a
quarter of the global population. Recently, host-gut microbiota metabolic interactions have …
quarter of the global population. Recently, host-gut microbiota metabolic interactions have …
Bile acid metabolism and signaling, the microbiota, and metabolic disease
The diversity, composition, and function of the bacterial community inhabiting the human
gastrointestinal tract contributes to host health through its role in producing energy or …
gastrointestinal tract contributes to host health through its role in producing energy or …
Reinforcement of the intestinal mucosal barrier via mucus-penetrating PEGylated bacteria
Y Chen, S Lin, L Wang, Y Zhang, H Chen… - Nature Biomedical …, 2024 - nature.com
The breakdown of the gut's mucosal barrier that prevents the infiltration of microorganisms,
inflammatory cytokines and toxins into bodily tissues can lead to inflammatory bowel …
inflammatory cytokines and toxins into bodily tissues can lead to inflammatory bowel …
[HTML][HTML] Role and mechanism of gut microbiota in human disease
Y Chen, J Zhou, L Wang - Frontiers in cellular and infection …, 2021 - frontiersin.org
The human gut microbiome is a huge microbial community that plays an irreplaceable role
in human life. With the further development of research, the influence of intestinal flora on …
in human life. With the further development of research, the influence of intestinal flora on …
Gut commensal Parabacteroides distasonis alleviates inflammatory arthritis
Objective Gut microbiota dysbiosis is closely linked to the pathogenesis of rheumatoid
arthritis (RA). We aimed to identify potential probiotic gut microbes that can ameliorate the …
arthritis (RA). We aimed to identify potential probiotic gut microbes that can ameliorate the …
Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity
The gut-brain axis is implicated in depression development, yet its underlying mechanism
remains unclear. We observed depleted gut bacterial species, including Bifidobacterium …
remains unclear. We observed depleted gut bacterial species, including Bifidobacterium …
Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling
J Zhong, X He, X Gao, Q Liu, Y Zhao, Y Hong… - Nature …, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is usually characterized with disrupted bile acid
(BA) homeostasis. However, the exact role of certain BA in NAFLD is poorly understood …
(BA) homeostasis. However, the exact role of certain BA in NAFLD is poorly understood …
Melatonin mitigates aflatoxin B1‐induced liver injury via modulation of gut microbiota/intestinal FXR/liver TLR4 signaling axis in mice
S Liu, W Kang, X Mao, L Ge, H Du, J Li… - Journal of pineal …, 2022 - Wiley Online Library
Abstract Aflatoxin B1 (AFB1) is a widespread contaminant in foods and feedstuffs, and its
target organ is the liver. Melatonin (MT) has been shown to alleviate inflammation in organs …
target organ is the liver. Melatonin (MT) has been shown to alleviate inflammation in organs …