The diverse metabolic roles of peripheral serotonin

AM Martin, RL Young, L Leong, GB Rogers… - …, 2017 - academic.oup.com
Abstract Serotonin (5-hydroxytryptamine or 5-HT) is a multifunctional bioamine with
important signaling roles in a range of physiological pathways. Almost all of the 5-HT in our …

Weight gain and antidepressants

M Fava - Journal of Clinical Psychiatry, 2000 - psychiatrist.com
Weight gain during antidepressant treatment can be either a sign of improvement in patients
who have weight loss as a symptom of depression or a residual symptom in patients who …

Antidepressant use and risk of adverse outcomes in older people: population based cohort study

C Coupland, P Dhiman, R Morriss, A Arthur, G Barton… - Bmj, 2011 - bmj.com
Objectives To investigate the association between antidepressant treatment and risk of
several potential adverse outcomes in older people with depression and to examine risks by …

[HTML][HTML] Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum

VK Yadav, JH Ryu, N Suda, KF Tanaka, JA Gingrich… - Cell, 2008 - cell.com
Loss-and gain-of-function mutations in the broadly expressed gene Lrp5 affect bone
formation, causing osteoporosis and high bone mass, respectively. Although Lrp5 is viewed …

Factors influencing early dental implant failures

BR Chrcanovic, J Kisch, T Albrektsson… - Journal of dental …, 2016 - journals.sagepub.com
The purpose of the present study was to assess the influence of local and systemic factors
on the occurrence of dental implant failures up to the second-stage surgery (abutment …

A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure

VK Yadav, F Oury, N Suda, ZW Liu, XB Gao… - Cell, 2009 - cell.com
Leptin inhibition of bone mass accrual requires the integrity of specific hypothalamic
neurons but not expression of its receptor on these neurons. The same is true for its …

The association between low vitamin D and depressive disorders

Y Milaneschi, W Hoogendijk, P Lips, AC Heijboer… - Molecular …, 2014 - nature.com
It has been hypothesized that hypovitaminosis D is associated with depression but
epidemiological evidence is limited. We investigated the association between depressive …

Use of proton pump inhibitors and risk of osteoporosis-related fractures

LE Targownik, LM Lix, CJ Metge, HJ Prior, S Leung… - Cmaj, 2008 - Can Med Assoc
Background: The use of proton pump inhibitors has been associated with an increased risk
of hip fracture. We sought to further explore the relation between duration of exposure to …

The complex interplay of depression and falls in older adults: a clinical review

A Iaboni, AJ Flint - The American Journal of Geriatric Psychiatry, 2013 - Elsevier
Depression and falls have a significant bidirectional relationship. Excessive fear of falling,
which is frequently associated with depression, also increases the risk of falls. Both …

Antidepressants for agitation and psychosis in dementia

DP Seitz, N Adunuri, SS Gill, A Gruneir… - Cochrane Database …, 2011 - cochranelibrary.com
Background Agitation and psychosis are common among older adults with dementia and
are challenging to manage. At the present time, little is known about the efficacy and safety …