Abstract PTEN, on 10q23. 3, encodes a major lipid phosphatase which signals down the
phosphoinositol‐3‐kinase/Akt pathway and effects G1 cell cycle arrest and apoptosis …

Germline mutations distributed across the PTEN tumor-suppressor gene have been found to
result in a wide spectrum of phenotypic features. Originally shown to be a major …

Background: PTEN tumor suppressor gene mutations are the most frequent genetic lesions
in endometrial adenocarcinomas of the endometrioid subtype. Testing the hypothesis that …

Germline mutations in the tumour suppressor gene PTEN have been implicated in two
hamartoma syndromes that exhibit some clinical overlap, Cowden syndrome (CS) and …

Cowden syndrome (CS, MIM 158350) is an autosomal dominant disorder with age related
penetrance characterised by multiple hamartomas and a high risk of breast, thyroid, and …

Initially identified in high-grade gliomas, mutations in the PTEN tumor-suppressor are also
found in many sporadic cancers and a few related autosomal dominant hamartoma …

Thyroid nodules are approximately 4 times more common in women than in men. Palpable
nodules increase in frequency throughout life, reaching a prevalence of approximately 5% in …

Inactivating mutations in the PTEN tumor suppressor gene, encoding a phosphatase, occur
in three related human autosomal dominant disorders characterized by tumor susceptibility …

PTEN (phosphatase and tensin homolog deleted on chromosome ten), a recently
discovered tumor suppressor gene, appears to negatively control the phosphoinositide 3 …

Cowden syndrome (CS) is a multi-system disease involving hamartomatous overgrowth of
tissues of all three embryonic origins and increased risks for thyroid, breast and possibly …