Discogenic back pain is one of the most diffused musculoskeletal pathologies and a hurdle
to a good quality of life for millions of people. Existing therapeutic options are exclusively …

Background Lower back pain, as a typical clinical symptom of spinal degenerative diseases,
is emerging as a major social problem. According to recent researches, the primary cause of …

The annulus fibrosus (AF), a permeable, hydrated, and fiber-reinforced soft tissue, exhibits
complex responses influenced by fluid pressure, osmotic pressure, and structural …

Background The ion channel transient receptor potential vanilloid 4 (TRPV4) critically
transduces mechanical forces in the IVD, and its inhibition can prevent IVD degeneration …

Abstract Background and Objective The degeneration of intervertebral discs is significantly
dependent of the changes in tissue composition ratio and tissue structure. Up to the present …

Finite element models are useful for investigating internal intervertebral disc (IVD)
behaviours without using disruptive experimental techniques. Simplified geometries are …

Physical disruptions to intervertebral discs (IVDs) can cause mechanical changes that lead
to degeneration and to low back pain which affects 75% of us in our lifetimes. Quantifying …

The intervertebral disc (IVD) plays a main role in absorbing and transmitting loads within the
spinal column. Degeneration alters the structural integrity of the IVDs and causes pain …

Background Intervertebral disc degeneration is often implicated in low back pain; however,
discs with structural degeneration often do not cause pain. It may be that disc mechanics can …

Medical imaging modalities that calculate tissue morphology alone cannot provide direct
information regarding the mechanical behaviour of load-bearing musculoskeletal organs …