Endometrial cancer is a clinically heterogeneous disease and it is becoming increasingly
clear that this heterogeneity may be a function of the diversity of the underlying molecular …

Lynch syndrome (LS) is an autosomal dominant genetic disorder associated with germline
mutations in DNA mismatch repair (MMR) genes. The carriers of pathogenic mutations in …

Simple Summary Lynch syndrome is the most common form of hereditary colorectal cancer
associate to variants in Mismatch Repair (MMR) genes. Unfortunately, a large amount of …

Alterations in short-repetitive DNA sequences, known as microsatellite instability (MSI), can
reflect deficiencies in Mismatch Repair (MMR) system which represents a major player in …

Molecular characterization of endometrial cancer into subgroups has prognostic and
therapeutic implications. Further development of an integrated molecular risk profile may …

The purpose of this article is to review the current molecular classification of endometrial
cancer, the imaging findings in early and advanced disease, and the current management …

The dual‐stratified pathway of endometrial carcinomas (ECs) has long been dominant.
However, in 2013, The Cancer Genome Atlas (TCGA) defined four EC subgroups with …

Microsatellite instability (MSI) represents one of the major types of genomic instability in
human cancers and is most common in colorectal cancer (CRC) and endometrial cancer …

Lynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer (HNPCC), is
a disorder caused by an autosomal dominant heterozygous germline mutation in one of the …

Cellular plasticity, the ability of cells to switch from an epitheial phenotype to a mesenchymal
one and vice versa, plays a crucial role in tumour progression and metastases development …