The molecular basis of erythrocyte invasion by malaria parasites

AF Cowman, CJ Tonkin, WH Tham, MT Duraisingh - Cell host & microbe, 2017 - cell.com
Plasmodium species cause malaria by proliferating in human erythrocytes. Invasion of
immunologically privileged erythrocytes provides a relatively protective niche as well as …

Erythrocyte glycophorins as receptors for Plasmodium merozoites

E Jaskiewicz, M Jodłowska, R Kaczmarek, A Zerka - Parasites & vectors, 2019 - Springer
Glycophorins are heavily glycosylated sialoglycoproteins of human and animal erythrocytes.
In humans, there are four glycophorins: A, B, C and D. Glycophorins play an important role in …

A comparison of microfluidic methods for high-throughput cell deformability measurements

M Urbanska, HE Muñoz, J Shaw Bagnall, O Otto… - Nature …, 2020 - nature.com
The mechanical phenotype of a cell is an inherent biophysical marker of its state and
function, with many applications in basic and applied biological research. Microfluidics …

Red blood cell tension protects against severe malaria in the Dantu blood group

SN Kariuki, A Marin-Menendez, V Introini, BJ Ravenhill… - Nature, 2020 - nature.com
Malaria has had a major effect on the human genome, with many protective polymorphisms—
such as the sickle-cell trait—having been selected to high frequencies in malaria-endemic …

Dual plasmepsin-targeting antimalarial agents disrupt multiple stages of the malaria parasite life cycle

P Favuzza, M de Lera Ruiz, JK Thompson, T Triglia… - Cell host & …, 2020 - cell.com
Artemisin combination therapy (ACT) is the main treatment option for malaria, which is
caused by the intracellular parasite Plasmodium. However, increased resistance to ACT …

Detection of human disease conditions by single-cell morpho-rheological phenoty** of blood

N Toepfner, C Herold, O Otto, P Rosendahl, A Jacobi… - elife, 2018 - elifesciences.org
Blood is arguably the most important bodily fluid and its analysis provides crucial health
status information. A first routine measure to narrow down diagnosis in clinical practice is the …

High-throughput single-cell rheology in complex samples by dynamic real-time deformability cytometry

B Fregin, F Czerwinski, D Biedenweg, S Girardo… - Nature …, 2019 - nature.com
In life sciences, the material properties of suspended cells have attained significance close
to that of fluorescent markers but with the advantage of label-free and unbiased sample …

CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

A Menny, M Serna, CM Boyd, S Gardner… - Nature …, 2018 - nature.com
The membrane attack complex (MAC) is one of the immune system's first responders.
Complement proteins assemble on target membranes to form pores that lyse pathogens and …

Effect of DMSO on the mechanical and structural properties of model and biological membranes

B Gironi, Z Kahveci, B McGill, BD Lechner, S Pagliara… - Biophysical journal, 2020 - cell.com
Dimethyl sulfoxide (DMSO) is widely used in a number of biological and biotechnological
applications, mainly because of its effects on the cell plasma membrane, but the molecular …

Image-based cell sorting using focused travelling surface acoustic waves

AA Nawaz, D Soteriou, CK Xu, R Goswami, M Herbig… - Lab on a Chip, 2023 - pubs.rsc.org
Sorting cells is an essential primary step in many biological and clinical applications such as
high-throughput drug screening, cancer research and cell transplantation. Cell sorting …