The question of how genomic information is expressed to determine phenotypes is of central
importance for basic and translational life science research and has been studied by …

Literature covered: early 2000s to late 2017 Bacteria frequently exchange metabolites with
other micro-and macro-organisms. In these often obligate cross-feeding interactions, primary …

Bacteria can be genetically engineered to kill specific pathogens or inhibit their virulence.
We previously developed a synthetic genetic system that allows a laboratory strain of …

The prediction of cellular function from a genotype is a fundamental goal in biology. For
metabolism, constraint-based modelling methods systematize biochemical, genetic and …

Reconstructed microbial metabolic networks facilitate a mechanistic description of the
genotype–phenotype relationship through the deployment of constraint-based …

A central aim of cell biology was to understand the strategy of gene expression in response
to the environment. Here, we study gene expression response to metabolic challenges in …

Dissimilatory sulphate reduction is the unifying and defining trait of sulphate-reducing
prokaryotes (SRP). In their predominant habitats, sulphate-rich marine sediments, SRP have …

The genome‐scale model (GEM) of metabolism in the bacterium Escherichia coli K‐12 has
been in development for over a decade and is now in wide use. GEM‐enabled studies of E …

Bacteria that have adapted to nutrient-rich, stable environments are typically characterized
by reduced genomes. The loss of biosynthetic genes frequently renders these lineages …

With the advent of high-throughput technologies, the field of systems biology has amassed
an abundance of “omics” data, quantifying thousands of cellular components across a …