Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by a
slow, progressive, and multifactorial degeneration of retinal ganglion cells (RGCs) and their …

Maintenance of plasma membrane integrity is essential for normal cell viability and function.
Thus, robust membrane repair mechanisms have evolved to counteract the eminent threat of …

The alteration and aggregation of alpha-synuclein (α-syn) play a crucial role in
neurodegenerative diseases collectively termed as synucleinopathies, including Parkinson's …

Microscopy of Lewy bodies in Parkinson's disease (PD) suggests they are not solely
filamentous deposits of α-synuclein (αS) but also contain vesicles and other membranous …

Heterozygous point mutations of α-synuclein (α-syn) have been linked to the early onset and
rapid progression of familial Parkinson's diseases (fPD). However, the interplay between …

Objective Parkinson disease (PD) has useful symptomatic treatments that do not slow the
neurodegenerative process, and no significant disease‐modifying treatments are approved …

Purpose Parkinson's disease (PD) is the second most common neurodegenerative disease.
The α-Synuclein is a major component of Lewy bodies and Lewy neurites, the pathologic …

While misfolding of alpha-synuclein (αSyn) is central to the pathogenesis of Parkinson's
disease (PD), fundamental questions about its structure and function at the synapse remain …

The heterogeneity of protein-rich inclusions and its significance in neurodegeneration is
poorly understood. Standard patient-derived iPSC models develop inclusions neither …

Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders affecting
the worldwide population. One of its hallmarks is the intraneuronal accumulation of insoluble …