Background Grip strength is a widely used and well-validated measure of overall health that
is increasingly understood to index risk for psychiatric illness and neurodegeneration in …

Objectives To investigate the prevalence of frailty in older adults living with dementia and
explore the differences in medication use according to frailty status. Design Systematic …

INTRODUCTION The use of applied modeling in dementia risk prediction, diagnosis, and
prognostics will have substantial public health benefits, particularly as “deep phenoty**” …

Background Physical frailty is a state of increased vulnerability to stressors and is associated
with serious health issues. However, how frailty affects and is affected by numerous other …

Frailty is an aging-related clinical phenotype defined as a state in which there is an increase
in a person's vulnerability for dependency and/or mortality when exposed to a stressor …

Background Plasma metabolomic profile is disturbed in dementia patients, but previous
studies have discordant conclusions. Methods Circulating metabolomic data of 110,655 …

Background Cross-sectional studies found that frailty was associated with prevalent diabetic
microvascular complications (DMC). Longitudinal evidence in this regard is inconclusive …

Importance Cross-sectional evidence implicates high prevalent frailty in patients with
Parkinson disease (PD), whereas the longitudinal association remains unknown. Objectives …

Background longitudinal evidence concerning frailty phenotype and the risk of
cardiovascular disease (CVD) remained insufficient, and whether CVD preventive strategies …

Handgrip strength (HGS), a measure of muscular strength, might be a risk indicator for
cognitive functioning, but the evidence is not consistent. Using a new prospective study and …