[HTML][HTML] Prognostic and Predictive Value of PBRM1 in Clear Cell Renal Cell Carcinoma
L Carril-Ajuria, M Santos, JM Roldán-Romero… - Cancers, 2019 - mdpi.com
Renal cell carcinoma (RCC) is the most frequent kidney solid tumor, the clear cell RCC
(ccRCC) being the major histological subtype. The probability of recurrence and the clinical …
(ccRCC) being the major histological subtype. The probability of recurrence and the clinical …
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice
R Hoefflin, S Harlander, S Schäfer, P Metzger… - Nature …, 2020 - nature.com
Mutational inactivation of VHL is the earliest genetic event in the majority of clear cell renal
cell carcinomas (ccRCC), leading to accumulation of the HIF-1α and HIF-2α transcription …
cell carcinomas (ccRCC), leading to accumulation of the HIF-1α and HIF-2α transcription …
[HTML][HTML] Recent advances in renal tumors with tsc/mtor pathway abnormalities in patients with tuberous sclerosis complex and in the sporadic setting
Simple Summary In the past decade, several novel renal neoplasms characterized by
mutations in the tuberous sclerosis complex (TSC) or mechanistic target of rapamycin …
mutations in the tuberous sclerosis complex (TSC) or mechanistic target of rapamycin …
Determinants of renal cell carcinoma invasion and metastatic competence
Metastasis is the principal cause of cancer related deaths. Tumor invasion is essential for
metastatic spread. However, determinants of invasion are poorly understood. We addressed …
metastatic spread. However, determinants of invasion are poorly understood. We addressed …
Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis
J Espana-Agusti, A Warren, SK Chew… - Nature …, 2017 - nature.com
Inactivation of the VHL (Von Hippel Lindau) tumour suppressor has long been recognised
as necessary for the pathogenesis of clear cell renal cancer (ccRCC); however, the …
as necessary for the pathogenesis of clear cell renal cancer (ccRCC); however, the …
A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma
SE Syafruddin, P Rodrigues, E Vojtasova… - Nature …, 2019 - nature.com
Transcriptional networks are critical for the establishment of tissue-specific cellular states in
health and disease, including cancer. Yet, the transcriptional circuits that control …
health and disease, including cancer. Yet, the transcriptional circuits that control …
PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth
Abstract p53 acetylation is indispensable for its transcriptional activity and tumor
suppressive function. However, the identity of reader protein (s) for p53 acetylation remains …
suppressive function. However, the identity of reader protein (s) for p53 acetylation remains …
Experimental and computational modeling for signature and biomarker discovery of renal cell carcinoma progression
Abstract Background Renal Cell Carcinoma (RCC) is difficult to treat with 5-year survival rate
of 10% in metastatic patients. Main reasons of therapy failure are lack of validated …
of 10% in metastatic patients. Main reasons of therapy failure are lack of validated …
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
The tumor suppressor and deubiquitinase (DUB) BAP1 and its Drosophila ortholog Calypso
assemble DUB complexes with the transcription regulators Additional sex combs-like …
assemble DUB complexes with the transcription regulators Additional sex combs-like …
Why the dual origins of high grade serous ovarian cancer matter
EK Colvin, VM Howell - Nature communications, 2020 - nature.com
Why the dual origins of high grade serous ovarian cancer matter | Nature Communications Skip
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