Lipids and lipid derivatives for RNA delivery

Y Zhang, C Sun, C Wang, KE Jankovic… - Chemical reviews, 2021 - ACS Publications
RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Wearable sensors: modalities, challenges, and prospects

J Heikenfeld, A Jajack, J Rogers, P Gutruf, L Tian… - Lab on a Chip, 2018 - pubs.rsc.org
Wearable sensors have recently seen a large increase in both research and
commercialization. However, success in wearable sensors has been a mix of both progress …

Pulsed field ablation for the treatment of atrial fibrillation: PULSED AF pivotal trial

A Verma, DE Haines, LV Boersma, N Sood, A Natale… - Circulation, 2023 - ahajournals.org
Background: Pulsed field ablation uses electrical pulses to cause nonthermal irreversible
electroporation and induce cardiac cell death. Pulsed field ablation may have effectiveness …

Membrane electroporation and electropermeabilization: mechanisms and models

T Kotnik, L Rems, M Tarek… - Annual review of …, 2019 - annualreviews.org
Exposure of biological cells to high-voltage, short-duration electric pulses causes a transient
increase in their plasma membrane permeability, allowing transmembrane transport of …

Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts

MP Stewart, R Langer, KF Jensen - Chemical reviews, 2018 - ACS Publications
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

High-voltage electrical pulses in oncology: irreversible electroporation, electrochemotherapy, gene electrotransfer, electrofusion, and electroimmunotherapy

B Geboers, HJ Scheffer, PM Graybill, AH Ruarus… - Radiology, 2020 - pubs.rsna.org
This review summarizes the use of high-voltage electrical pulses (HVEPs) in clinical
oncology to treat solid tumors with irreversible electroporation (IRE) and …

A comprehensive review of small interfering RNAs (siRNAs): mechanism, therapeutic targets, and delivery strategies for cancer therapy

J Zhang, B Chen, C Gan, H Sun, J Zhang… - International journal of …, 2023 - Taylor & Francis
Small interfering RNA (siRNA) delivery by nanocarriers has been identified as a promising
strategy in the study and treatment of cancer. Short nucleotide sequences are synthesized …

Soft bioelectronics for therapeutics

Z Zhang, Z Zhu, P Zhou, Y Zou, J Yang, H Haick… - ACS …, 2023 - ACS Publications
Soft bioelectronics play an increasingly crucial role in high-precision therapeutics due to
their softness, biocompatibility, clinical accuracy, long-term stability, and patient-friendliness …

Recent advancements in electroporation technologies: from bench to clinic

SN Campelo, PH Huang, CR Buie… - Annual review of …, 2023 - annualreviews.org
Over the past decade, the increased adoption of electroporation-based technologies has led
to an expansion of clinical research initiatives. Electroporation has been utilized in …

Electroporation-based applications in biotechnology

T Kotnik, W Frey, M Sack, SH Meglič, M Peterka… - Trends in …, 2015 - cell.com
Electroporation is already an established technique in several areas of medicine, but many
of its biotechnological applications have only started to emerge; we review here some of the …