Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …

Antimicrobial-resistant ESKAPE (E nterococcus faecium, S taphylococcus aureus, K
lebsiella pneumoniae, A cinetobacter baumannii, P seudomonas aeruginosa, and E …

Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus are both common
commensals and major opportunistic human pathogens. In recent decades, these bacteria …

Osteomyelitis is a major complication of orthopedic diseases with high recurrence and
morbidity, along with long hospital stays and high medical costs. The conventional treatment …

For many years, ionophores have been used to control coccidiosis in poultry. However,
misuse of ionophores can cause toxicity with significant clinical symptoms. The most critical …

Implant-related infections caused by drug-resistant bacteria remain a major challenge faced
by orthopedic surgeons. Furthermore, ideal prevention and treatment methods are lacking in …

The search for new antimicrobials is imperative due to the emergent resistance of new
microorganism strains. In this context, revisiting known classes like 8-hydroxyquinolines …

Zinc is an essential micronutrient, and its deficiency is perhaps the most prevalent and least
understood worldwide. Recent advances have expanded the understanding of zinc's unique …

The increasing resistance of bacteria to commercially available antibiotics threatens patient
safety in healthcare settings. Perturbation of ion homeostasis has emerged as a potential …

Streptococcus pneumoniae is the primary cause of community-acquired bacterial
pneumonia with rates of penicillin and multidrug-resistance exceeding 80% and 40 …