Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …

Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, and scientific studies consistently report that NAFLD development can be …

Aging is a natural process, which plays a critical role in the pathogenesis of a variety of
diseases, ie, aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease …

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …

Metformin can improve patients' hyperglycemia through significant suppression of hepatic
glucose production. However, up to 300 times higher concentrations of metformin …

Cardiovascular diseases (CVDs) contribute to a large part of worldwide mortality. Similarly,
two of the major risk factors for these diseases, aging and obesity, are also global problems …

Metformin is currently the first-line drug treatment for type 2 diabetes. Besides its glucose-
lowering effect, there is interest in actions of the drug of potential relevance to cardiovascular …

Brown adipose tissue (BAT) combusts high amounts of fatty acids, thereby lowering plasma
triglyceride levels and reducing obesity. However, the precise role of BAT in plasma …

Metformin is a biguanide drug that has been used to treat type 2 diabetes mellitus for more
than 60 years. The United Kingdom Prospective Diabetic Study (UKPDS) has shown …