Given recent advances in phasing methods, those new to protein crystallography may be
forgiven for askingwhat problem?'. As many of those attending the CCP4 meeting come from …

Acylation of biomolecules (eg, proteins and small molecules) is a process that occurs in cells
of all domains of life and has emerged as a critical mechanism for the control of many …

Nuclear ribonuclease (RNase) P is a ubiquitous essential ribonucleoprotein complex, one of
only two known RNA-based enzymes found in all three domains of life. The RNA component …

The genomic DNA of all organisms across the three kingdoms of life needs to be compacted
and functionally organized. Key players in these processes are DNA supercoiling …

Alba domain-containing proteins are ubiquitously found in archaea and eukaryotes. By
binding to either DNA, RNA, or DNA: RNA hybrids, these proteins function in genome …

One of the first hurdles to be negotiated in the postgenomic era involves the description of
the entire protein content of the cell, the proteome. Such efforts are presently complicated by …

Tubulin, the protein subunit of microtubules (MTs), is an α/β heterodimer. In this chapter, a
hypothesis on the evolution of the tubulin molecule is proposed, based in part on recent …

The CRISPR–Cas system for prokaryotic adaptive immunity provides RNA-mediated
protection from viruses and mobile genetic elements. Adaptation is dependent on the Cas1 …

In eukaryotes, histone paralogues form obligate heterodimers such as H3/H4 and H2A/H2B
that assemble into octameric nucleosome particles. Archaeal histones are dimeric and …

Background There is considerable heterogeneity in the phyletic patterns of major
chromosomal DNA-binding proteins in archaea. Alba is a well-characterized chromosomal …