Does transcutaneous auricular vagus nerve stimulation affect vagally mediated heart rate variability? A living and interactive Bayesian meta‐analysis

V Wolf, A Kühnel, V Teckentrup, J Koenig… - …, 2021 - Wiley Online Library
Non‐invasive brain stimulation techniques, such as transcutaneous auricular vagus nerve
stimulation (taVNS), have considerable potential for clinical use. Beneficial effects of taVNS …

Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues

H Dobrzynski, RH Anderson, A Atkinson… - Pharmacology & …, 2013 - Elsevier
It is now over 100years since the discovery of the cardiac conduction system, consisting of
three main parts, the sinus node, the atrioventricular node and the His–Purkinje system. The …

Transcriptomic profiling of the develo** cardiac conduction system at single-cell resolution

WR Goodyer, BM Beyersdorf, DT Paik, L Tian… - Circulation …, 2019 - Am Heart Assoc
Rationale: The cardiac conduction system (CCS) consists of distinct components including
the sinoatrial node, atrioventricular node, His bundle, bundle branches, and Purkinje fibers …

Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing

D Liang, J Xue, L Geng, L Zhou, B Lv, Q Zeng… - Nature …, 2021 - nature.com
Bioelectrical impulses intrinsically generated within the sinoatrial node (SAN) trigger the
contraction of the heart in mammals. Though discovered over a century ago, the molecular …

A deep learning approach for atrial fibrillation classification using multi-feature time series data from ecg and ppg

B Aldughayfiq, F Ashfaq, NZ Jhanjhi, M Humayun - Diagnostics, 2023 - mdpi.com
Atrial fibrillation is a prevalent cardiac arrhythmia that poses significant health risks to
patients. The use of non-invasive methods for AF detection, such as Electrocardiogram and …

HCN4 Mutations in Multiple Families With Bradycardia and Left Ventricular Noncompaction Cardiomyopathy

A Milano, AMC Vermeer, EM Lodder, J Barc… - Journal of the American …, 2014 - jacc.org
Background: Familial forms of primary sinus bradycardia have sometimes been attributed to
mutations in HCN4, SCN5A, and ANK2. In these studies, no structural cardiac alterations …

[HTML][HTML] Biology of the sinus node and its disease

M Choudhury, MR Boyett, GM Morris - … & electrophysiology review, 2015 - ncbi.nlm.nih.gov
The sinoatrial node (SAN) is the normal pacemaker of the heart and SAN dysfunction (SND)
is common, but until recently the pathophysiology was incompletely understood. It was …

Fibrosis: a structural modulator of sinoatrial node physiology and dysfunction

TA Csepe, A Kalyanasundaram, BJ Hansen… - Frontiers in …, 2015 - frontiersin.org
Heart rhythm is initialized and controlled by the Sinoatrial Node (SAN), the primary
pacemaker of the heart. The SAN is a heterogeneous multi-compartment structure …

Cardiac pacemaker activity and aging

CH Peters, EJ Sharpe, C Proenza - Annual review of physiology, 2020 - annualreviews.org
A progressive decline in maximum heart rate (mHR) is a fundamental aspect of aging in
humans and other mammals. This decrease in mHR is independent of gender, fitness, and …

What makes the sinoatrial node tick? A question not for the faint of heart

L Donald, EG Lakatta - Philosophical Transactions of the …, 2023 - royalsocietypublishing.org
Even before the sinoatrial node (SAN) was discovered, cardiovascular science was
engaged in an active investigation of when and why the heart would beat. After the …