Mammary cancer, or breast cancer in women, is a polygenic disease with a complex
etiopathogenesis. While much remains elusive regarding its origin, it is well established that …

Genome-wide association studies (GWASs) have identified more than 200 genomic loci for
breast cancer risk, but specific causal genes in most of these loci have not been identified. In …

Deep sequencing is a term that has become embedded in the plant genomic literature in
recent years and with good reason. A torrent of (largely) high‐quality genomic and …

Transcriptome-wide association studies (TWAS) have successfully discovered many
putative disease susceptibility genes. However, TWAS may suffer from inaccuracy of gene …

By combining data from 160,500 individuals with breast cancer and 226,196 controls of
Asian and European ancestry, we conducted genome-and transcriptome-wide association …

Splicing-based transcriptome-wide association studies (splicing-TWASs) of breast cancer
have the potential to identify susceptibility genes. However, existing splicing-TWASs test the …

Multiple reference panels of a given tissue or multiple tissues often exist, and multiple
regression methods could be used for training gene expression imputation models for …

Human bulk tissue samples comprise multiple cell types with diverse roles in disease
etiology. Conventional transcriptome-wide association study approaches predict genetically …

Breast cancer genome-wide association studies (GWASs) have identified 150 genomic risk
regions containing more than 13,000 credible causal variants (CCVs). The CCVs are …

Genome-wide association studies have identified approximately 200 genetic risk loci for
breast cancer, but the causal variants and target genes are mostly unknown. We sought to …