Recent updates on thienopyrimidine derivatives as anticancer agents
Thienopyrimidine derivatives hold a unique place between fused pyrimidine compounds.
They are important and widely represented in medicinal chemistry as they are structural …
They are important and widely represented in medicinal chemistry as they are structural …
In-silico screening of novel synthesized thienopyrimidines targeting fms related receptor tyrosine kinase-3 and their in-vitro biological evaluation
The present investigation describes the design strategy and synthesis of novel
thienopyrimidine compounds in addition to their anticancer activity targeting tyrosine kinase …
thienopyrimidine compounds in addition to their anticancer activity targeting tyrosine kinase …
In silico screening and anticancer-apoptotic evaluation of newly synthesized thienopyrimidine/sulfonamide hybrids
EI Elmongy, FA Binjubair, OY Alshehri… - International Journal of …, 2023 - mdpi.com
This work describes the design and synthesis of new hybrids of thienopyrimidine and
sulfonamides. The binding affinity of the prepared compounds to FGFR-1 enzyme and …
sulfonamides. The binding affinity of the prepared compounds to FGFR-1 enzyme and …
Advances in structural identification of some thieno [2, 3-d] pyrimidine scaffolds as antitumor molecules: Synthetic approaches and control programmed cancer cell …
Abstract Thieno [2, 3-d] pyrimidine fragment is not only bioistostere to quinazoline ring but
also to purines which exist in nucleic acids responsible for several key biological processes …
also to purines which exist in nucleic acids responsible for several key biological processes …
Synthesis, Biocidal and Antibiofilm Activities of New Isatin–Quinoline Conjugates against Multidrug-Resistant Bacterial Pathogens along with Their In Silico Screening
Isatin–quinoline conjugates 10a–f and 11a–f were assembled by the reaction of N-
(bromobutyl) isatin derivatives 3a, b with aminoquinolines 6a–c and their corresponding …
(bromobutyl) isatin derivatives 3a, b with aminoquinolines 6a–c and their corresponding …
Design and cytotoxic evaluation via apoptotic and antiproliferative activity for novel 11 (4-aminophenylamino) neocryptolepine on hepatocellular and colorectal cancer …
The current study evaluated the cytotoxic activity of 11 (4-Aminophenylamino)
neocryptolepine (APAN), a novel derivative of neocryptolepine, on hepatocellular (HepG2) …
neocryptolepine (APAN), a novel derivative of neocryptolepine, on hepatocellular (HepG2) …
Design, synthesis, and antiproliferative activity of novel neocryptolepine–rhodanine hybrids
M El-Bahnsawye, MKA Hussein, EI Elmongy, HM Awad… - Molecules, 2022 - mdpi.com
A series of novel neocryptolepine–rhodanine hybrids (9a, b, 11a–d, 14, and 16a, b) have
been synthesized by combining neocryptolepine core 5 modified at the C-11 position with …
been synthesized by combining neocryptolepine core 5 modified at the C-11 position with …
In silico evaluation of a promising key intermediate thieno [2, 3-d] pyrimidine derivative with expected JAK2 kinase inhibitory activity
This work describes the synthesis and the cytotoxic evaluation of thiophene and
thienopyrimidine derivatives. The investigated compound was subjected to target prediction …
thienopyrimidine derivatives. The investigated compound was subjected to target prediction …
A decade's overview of 2‐aminothiophenes and their fused analogs as promising anticancer agents
DG Darwish, HAM El‐Sherief… - Archiv der …, 2024 - Wiley Online Library
Over the past decades, cancer has been a challenging domain for medicinal chemists as it
is an international health concern. In association, small molecules such as 2 …
is an international health concern. In association, small molecules such as 2 …
Design, synthesis and anticancer evaluation of 4-Substituted 5, 6, 7, 8-tetrahydrobenzo [4, 5] thieno [2, 3-d] pyrimidines as dual topoisomerase I and II inhibitors
In this study, we herein report the design, synthesis, and anticancer assessment of a series
of new 4-substituted 5, 6, 7, 8-tetrahydrobenzo [4, 5] thieno [2, 3-d] pyrimidines. The …
of new 4-substituted 5, 6, 7, 8-tetrahydrobenzo [4, 5] thieno [2, 3-d] pyrimidines. The …