Voltage-gated calcium channels couple depolarization of the cell-surface membrane to entry
of calcium, which triggers secretion, contraction, neurotransmission, gene expression, and …

Chemical synapses are heterogeneous junctions formed between neurons that are
specialized for the conversion of electrical impulses into the exocytotic release of …

The ability of the brain to store and process information relies on changing the strength of
connections between neurons. Synaptic facilitation is a form of short-term plasticity that …

Different types of synapses are specialized to interpret spike trains in their own way by virtue
of the complement of short-term synaptic plasticity mechanisms they possess. Numerous …

The intracellular calcium concentration ([Ca 2+]) has important roles in the triggering of
neurotransmitter release and the regulation of short-term plasticity (STP). Transmitter …

Voltage-gated calcium (Ca 2+) channels initiate release of neurotransmitters at synapses,
and regulation of presynaptic Ca 2+ channels has a powerful influence on synaptic strength …

Synapses exhibit several forms of short-term plasticity that play a multitude of computational
roles. Short-term depression suppresses neurotransmitter release for hundreds of …

At presynaptic active zones, neurotransmitter release is initiated by the opening of voltage-
gated Ca 2+ channels close to docked vesicles. The mechanisms that enrich Ca 2+ …

Vesicle fusion and transmitter release at synapses is driven by a highly localized Ca2+
signal that rapidly builds up around open Ca2+-channels at and near presynaptic active …

Long-term synaptic plasticity is a major cellular substrate for learning, memory, and
behavioral adaptation. Although early examples of long-term synaptic plasticity described a …