The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

Pyridine (py) is an important heterocyclic compound and is an integral part of various natural
products. There are various medicines containing py ring system being available in the …

Thiosemicarbazones (TSCs) are a class of Schiff bases usually obtained by the
condensation of thiosemicarbazide with a suitable aldehyde or ketone. TSCs have been the …

DNA topoisomerase II (topo II) is an important enzyme involved in DNA replication,
recombination, and repair. Despite the popular applications of topo II inhibitors in cancer …

DNA Topoisomerases (Topos) are ubiquitous nuclear enzymes involved in regulating the
topological state of DNA and, in eukaryotic organisms, Topos can be classified into two …

DNA is considered one of the most promising targets of molecules with anticancer activity
potential. Its key role in various cell division mechanisms, which commands the intense …

A new series of aza-indeno [1, 2-b] pyridin-5-one derivatives 6a-h was designed. The novel
pyridin-5-one derivatives were constructed via cyclization of their corresponding hydrazonal …

Structurally simple chalcone derivatives 1–2 are prepared and their diversified emission
behaviors are deeply investigated. Two polymorphs (1G: λem= 536 nm, Φf= 0.08, τ= 1.81 ns; …

Dynamic molecular crystals have attracted considerable attention as smart materials for
promising applications in high-technology areas. The dynamic behaviors of bending …

Widespread outbreak of numerous infectious diseases and metabolic disorders across the
globe has created awareness among the chemists for novel design and synthesis of natural …