Post-traumatic stress disorder (PTSD) is the only major mental disorder for which a cause is
considered to be known: that is, an event that involves threat to the physical integrity of …

Stress is a primary risk factor for several neuropsychiatric disorders. Evidence from
preclinical models and clinical studies of depression have revealed an array of structural …

Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

Microglia are the predominant immune cells of the central nervous system (CNS) that exert
key physiological roles required for maintaining CNS homeostasis, notably in response to …

Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

Childhood maltreatment is a major risk factor for chronic and severe mental and physical
health problems across the lifespan. Increasing evidence supports the hypothesis that …

Context Our genome adapts to environmental influences, in part through epigenetic
mechanisms, including DNA methylation. Variations in the quality of the early environment …

Recent years have seen increased interest in psychopathologies related to trauma
exposure. Specifically, there has been a growing awareness to posttraumatic stress disorder …

Variation in maternal care can lead to divergent developmental trajectories in offspring with
implications for neuroendocrine function and behavioral phenotypes. Study of the long-term …

Extensive research has identified stereotypic behavioral and biological abnormalities in post-
traumatic stress disorder (PTSD), such as heightened autonomic activity, an exaggerated …