Neuroscientists today can measure activity from more neurons than ever before, and are
facing the challenge of connecting these brain-wide neural recordings to computation and …

The past decade has witnessed remarkable advances in the simultaneous measurement of
neuronal activity across many brain regions, enabling fundamentally new explorations of the …

The anatomy of the mammalian visual system, from the retina to the neocortex, is organized
hierarchically. However, direct observation of cellular-level functional interactions across this …

Recent studies have shown that neuronal representations gradually change over time
despite no changes in the stimulus, environment, or behavior. However, such …

Progress in many scientific disciplines is hindered by the presence of independent noise.
Technologies for measuring neural activity (calcium imaging, extracellular electrophysiology …

Nullius in verba ('trust no one'), chosen as the motto of the Royal Society in 1660, implies
that independently verifiable observations—rather than authoritative claims—are a defining …

Inference of action potentials ('spikes') from neuronal calcium signals is complicated by the
scarcity of simultaneous measurements of action potentials and calcium signals ('ground …

Sensory cortices can be affected by stimuli of multiple modalities and are thus increasingly
thought to be multisensory. For instance, primary visual cortex (V1) is influenced not only by …

Multi-electrode arrays such as Neuropixels probes enable electrophysiological recordings
from large populations of single neurons with high temporal resolution. By using such …

Neuropixels are silicon-based electrophysiology-recording probes with high channel count
and recording-site density. These probes offer a turnkey platform for measuring neural …