Mechanisms and consequences of sex differences in immune responses
Biological sex differences refer to differences between males and females caused by the sex
chromosome complement (that is, XY or XX), reproductive tissues (that is, the presence of …
chromosome complement (that is, XY or XX), reproductive tissues (that is, the presence of …
Sex shapes gut–microbiota–brain communication and disease
KC Hokanson, C Hernández, GE Deitzler… - Trends in …, 2024 - cell.com
Research into the microbiota–gut–brain axis (MGBA) has entered a golden age, raising the
hope that therapeutics acting on it may offer breakthroughs in the treatment of many …
hope that therapeutics acting on it may offer breakthroughs in the treatment of many …
Why the estrous cycle matters for neuroscience
Background Ovarian hormone fluctuations over the rodent estrous cycle and the human
menstrual cycle are known to significantly impact brain physiology and disease risk, yet this …
menstrual cycle are known to significantly impact brain physiology and disease risk, yet this …
Amplification is the primary mode of gene-by-sex interaction in complex human traits
Sex differences in complex traits are suspected to be in part due to widespread gene-by-sex
interactions (GxSex), but empirical evidence has been elusive. Here, we infer the mixture of …
interactions (GxSex), but empirical evidence has been elusive. Here, we infer the mixture of …
[HTML][HTML] Sex diversity in the 21st century: Concepts, frameworks, and approaches for the future of neuroendocrinology
Sex is ubiquitous and variable throughout the animal kingdom. Historically, scientists have
used reductionist methodologies that rely on a priori sex categorizations, in which two …
used reductionist methodologies that rely on a priori sex categorizations, in which two …
Quality control and analytic best practices for testing genetic models of sex differences in large populations
Phenotypic sex-based differences exist for many complex traits. In other cases, phenotypes
may be similar, but underlying biology may vary. Thus, sex-aware genetic analyses are …
may be similar, but underlying biology may vary. Thus, sex-aware genetic analyses are …
[HTML][HTML] Deconstructing sex: Strategies for undoing binary thinking in neuroendocrinology and behavior
The scientific community widely recognizes that “sex” is a complex category composed of
multiple physiologies. Yet in practice, basic scientific research often treats “sex” as a single …
multiple physiologies. Yet in practice, basic scientific research often treats “sex” as a single …
What's fair is… fair? Presenting JustEFAB, an ethical framework for operationalizing medical ethics and social justice in the integration of clinical machine learning …
The problem of algorithmic bias represents an ethical threat to the fair treatment of patients
when their care involves machine learning (ML) models informing clinical decision-making …
when their care involves machine learning (ML) models informing clinical decision-making …
A normative framework for artificial intelligence as a sociotechnical system in healthcare
Artificial intelligence (AI) tools are of great interest to healthcare organizations for their
potential to improve patient care, yet their translation into clinical settings remains …
potential to improve patient care, yet their translation into clinical settings remains …
[HTML][HTML] The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan
Prenatal alcohol exposure (PAE) can reprogram the development of cells and tissues,
resulting in a spectrum of physical and neurobehavioral teratology. PAE immediately …
resulting in a spectrum of physical and neurobehavioral teratology. PAE immediately …