Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications
Y Li, Y Liu, XY Yu, Y Xu, X Pan, Y Sun… - … and Targeted Therapy, 2024 - nature.com
Once considered unconventional cellular structures, membraneless organelles (MLOs),
cellular substructures involved in biological processes or pathways under physiological …
cellular substructures involved in biological processes or pathways under physiological …
The Emerging Roles of Multimolecular G-Quadruplexes in Transcriptional Regulation and Chromatin Organization
NF Antariksa, M Di Antonio - Accounts of Chemical Research, 2024 - ACS Publications
Conspectus The ability of genomic DNA to adopt non-canonical secondary structures known
as G-quadruplexes (G4s) under physiological conditions has been recognized for its …
as G-quadruplexes (G4s) under physiological conditions has been recognized for its …
Cellular Visualization of G-Quadruplex RNA via Fluorescence-Lifetime Imaging Microscopy
Over the past decade, appreciation of the roles of G-quadruplex (G4) structures in cellular
regulation and maintenance has rapidly grown, making the establishment of robust methods …
regulation and maintenance has rapidly grown, making the establishment of robust methods …
CRISPR/Cas13d targeting suppresses repeat-associated non-AUG translation of C9orf72 hexanucleotide repeat RNA
A hexanucleotide GGGGCC repeat expansion in the non-coding region of the C9orf72 gene
is the most common genetic mutation identified in patients with amyotrophic lateral sclerosis …
is the most common genetic mutation identified in patients with amyotrophic lateral sclerosis …
RNA structure promotes liquid-to-solid phase transition of short RNAs in neuronal dysfunction
S Wang, Y Xu - Communications Biology, 2024 - nature.com
In nucleotide expansion disorders, RNA foci are reportedly associated with
neurodegenerative disease pathogeneses. Characteristically, these RNAs exhibit long poly …
neurodegenerative disease pathogeneses. Characteristically, these RNAs exhibit long poly …
[HTML][HTML] Restoring Homeostasis: Treating Amyotrophic Lateral Sclerosis by Resolving Dynamic Regulatory Instability
Amyotrophic lateral sclerosis (ALS) has an interactive, multifactorial etiology that makes
treatment success elusive. This study evaluates how regulatory dynamics impact disease …
treatment success elusive. This study evaluates how regulatory dynamics impact disease …
The effect of dipeptide repeat proteins on FUS/TDP43-RNA condensation in C9orf72 ALS/FTD
Condensation of RNA binding proteins (RBPs) with RNA is essential for cellular function.
The most common familial cause of the diseases ALS and FTD is C9orf72 repeat expansion …
The most common familial cause of the diseases ALS and FTD is C9orf72 repeat expansion …
Interaction-Dependent Secondary Structure of Peptides in Biomolecular Condensates
Biomolecular condensates provide a mechanism for compartmentalization of biomolecules
in eukaryotic cells. These liquid-like condensates are formed via liquid–liquid phase …
in eukaryotic cells. These liquid-like condensates are formed via liquid–liquid phase …
Crystal structure of a tetrameric RNA G-quadruplex formed by hexanucleotide repeat expansions of C9orf72 in ALS/FTD
Y Geng, C Liu, N Xu, MC Suen, H Miao… - Nucleic Acids …, 2024 - academic.oup.com
The abnormal GGGGCC hexanucleotide repeat expansions (HREs) in C9orf72 cause the
fatal neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal …
fatal neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal …
Small CAG Repeat RNA Forms a Duplex Structure with Sticky Ends That Promote RNA Condensation
Biomolecular condensation lays the foundation of forming biologically important
membraneless organelles, but abnormal condensation processes are often associated with …
membraneless organelles, but abnormal condensation processes are often associated with …