Intrinsically disordered proteins and regions (collectively, IDRs) are pervasive across
proteomes in all kingdoms of life, help to shape biological functions and are involved in …

Parkinson's disease (PD) is a common and incurable neurodegenerative disorder that
arises from the loss of dopaminergic neurons in the substantia nigra and is mainly …

The degradation of damaged proteins is critical for tissue integrity and organismal health
because damaged proteins have a high propensity to form aggregates. E3 ubiquitin ligases …

Proteostasis can be disturbed by mutations affecting folding and stability of the encoded
protein. An example is the ubiquitin ligase Parkin, where gene variants result in autosomal …

Unstable proteins are prone to form non-native interactions with other proteins and thereby
may become toxic. To mitigate this, destabilized proteins are targeted by the protein quality …

Intrinsically disordered proteins and regions (collectively IDRs) are pervasive across
proteomes in all kingdoms of life, help shape biological functions, and are involved in …

More than half of disease-causing missense variants are thought to lead to protein
degradation, but the molecular mechanism of how these variants are recognized by the cell …

Protein quality control (PQC) degrons are short protein segments that target misfolded
proteins for proteasomal degradation, and thus protect cells against the accumulation of …

Effective proteome homeostasis is key to cellular and organismal survival, and cells
therefore contain efficient quality control systems to monitor and remove potentially toxic …

Protein quality control (PQC) mechanisms are essential for degradation of misfolded or
dysfunctional proteins. An essential part of protein homeostasis is recognition of defective …