Microglia are implicated in all stages of multiple sclerosis (MS). Microglia alterations are
detected by positron emission tomography in people living with MS prior to the formation of …

One of the leading causes of neurological mortality, disability, and dementia worldwide is
cerebral ischemia. Among the many pathological phenomena, the immune system plays an …

Microglia are emerging as key drivers of neurological diseases. However, we lack a
systematic understanding of the underlying mechanisms. Here, we present a screening …

Nerve regeneration in adult mammalian spinal cord is poor because of the lack of intrinsic
regeneration of neurons and extrinsic factors–the glial scar is triggered by injury and inhibits …

Oxidative stress and mitochondrial dysfunction have been believed to play an important role
in the pathogenesis of aging and neurodegenerative diseases, including Parkinson's …

Frontotemporal dementia (FTD) is an incurable group of early-onset dementias that can be
caused by the deposition of hyperphosphorylated tau in patient brains. However, the …

The innate immune landscape of the central nervous system (CNS), including the brain and
the retina, consists of different myeloid cell populations with distinct tasks to fulfill. Whereas …

Alzheimer's disease (AD) is the most common type of cognitive impairment. AD is closely
related to orthopedic diseases, such as osteoporosis and osteoarthritis, in terms of …

Introduction: Multiple Sclerosis (MS) is the most common immune-mediated chronic
neurodegenerative disease of the central nervous system (CNS) affecting young people …

Microglia are the immune sentinels of the central nervous system with protective roles such
as the removal of neurotoxic oxidized phosphatidylcholines (OxPCs). As aging alters …