The 1, 2, 3-triazole ring as a bioisostere in medicinal chemistry
E Bonandi, MS Christodoulou, G Fumagalli… - Drug Discovery …, 2017 - Elsevier
Highlights•Triazoles mimic different functional groups, resulting optimal bioisosteres for the
synthesis of new active molecules.•Triazoles present a marked stability under hydrolytic …
synthesis of new active molecules.•Triazoles present a marked stability under hydrolytic …
[HTML][HTML] Mechanisms of biotin-regulated gene expression in microbes
Biotin is an essential micronutrient that acts as a co-factor for biotin-dependent metabolic
enzymes. In bacteria, the supply of biotin can be achieved by de novo synthesis or import …
enzymes. In bacteria, the supply of biotin can be achieved by de novo synthesis or import …
Identification of Putative Vaccine and Drug Targets against the Methicillin-Resistant Staphylococcus aureus by Reverse Vaccinology and Subtractive Genomics …
Methicillin-resistant Staphylococcus aureus (MRSA) is an opportunistic pathogen and
responsible for causing life-threatening infections. The emergence of hypervirulent and …
responsible for causing life-threatening infections. The emergence of hypervirulent and …
Antibacterial silver and gold complexes of imidazole and 1, 2, 4-triazole derived N-heterocyclic carbenes
A series of gold (I)(4a–4h, 5a–5b) and silver (I)(3a–3h) complexes of 1, 2, 4-triazolylidene
and imidazolylidene based N-heterocyclic carbene ligands were prepared and the …
and imidazolylidene based N-heterocyclic carbene ligands were prepared and the …
Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants
Weeds are becoming increasingly resistant to our current herbicides, posing a significant
threat to agricultural production. Therefore, new herbicides with novel modes of action are …
threat to agricultural production. Therefore, new herbicides with novel modes of action are …
Synthesis, antimicrobial activity and molecular docking studies of spiroquinoline-indoline-dione and spiropyrazolo-indoline-dione derivatives
Abstract Spiro [benzo [h] quinoline-7, 3′-indoline] diones and spiro [indoline-3, 4′-
pyrazolo [3, 4-b] quinoline] diones were efficiently synthesized via one-pot multi-component …
pyrazolo [3, 4-b] quinoline] diones were efficiently synthesized via one-pot multi-component …
Synthesis, antimicrobial activity and in-silico docking of two macrocycles based on pyrazole-tetrazole subunit
M Cherfi, T Harit, MI Yahyaoui, A Riahi… - Journal of Molecular …, 2022 - Elsevier
The design of two new macrocycles bearing two pyrazole-tetrazole subunits and a lateral
arm is presented. These macrocycles and the intermediate compounds are characterized by …
arm is presented. These macrocycles and the intermediate compounds are characterized by …
Synthesis of novel tetrazolic derivatives and evaluation of their antimicrobial activity
C Bourhou, H Benouda, R Bellaouchi… - Journal of Molecular …, 2023 - Elsevier
The microbial resistance to various anti-infective drugs remains a major worldwide health
problem. Therefore, the search for novel and effective antimicrobial agents is of paramount …
problem. Therefore, the search for novel and effective antimicrobial agents is of paramount …
Kinetic target-guided synthesis in drug discovery and chemical biology: a comprehensive facts and figures survey
For the last 15 years, kinetic target-guided syntheses, including in situ click chemistry, have
been used as alternative methods to find ligands to therapeutically relevant proteins. In this …
been used as alternative methods to find ligands to therapeutically relevant proteins. In this …
Repurposed inhibitor of bacterial dihydrodipicolinate reductase exhibits effective herbicidal activity
Herbicide resistance represents one of the biggest threats to our natural environment and
agricultural sector. Thus, new herbicides are urgently needed to tackle the rise in herbicide …
agricultural sector. Thus, new herbicides are urgently needed to tackle the rise in herbicide …