E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination
cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2 …

NEDD8 (neural precursor cell expressed developmentally downregulated protein 8) is a
ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin–RING …

Copper plays pivotal roles in metabolic homoeostasis, but its potential role in human
tumorigenesis is not well defined. Here, it is revealed that copper activates the …

Different polyubiquitin chain linkages direct substrates toward distinct cellular pathways. K63-
linked ubiquitylation is known to regulate proteasome-independent events such as signal …

Ubiquitin (Ub) chain formation by homologous to E6AP C-terminus (HECT)-family E3 ligases
regulates vast biology, yet the structural mechanisms remain unknown. We used chemistry …

The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double
RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain …

Ubiquitin chains of distinct topologies control the stability, interactions, or localization of
many proteins in eukaryotic cells, and thus play an essential role in cellular information …

Ubiquitination plays a pivotal role in several cellular processes and is critical for protein
degradation and signaling. E3 ubiquitin ligases are the matchmakers in the ubiquitination …

Several ubiquitin chain types have remained unstudied, mainly because tools and
techniques to detect these posttranslational modifications are scarce. Linkage-specific …

Strictly regulated protein degradation by ubiquitin-proteasome system (UPS) is essential for
various cellular processes whose dysregulation is linked to serious diseases including …