Engineering the vasculature for islet transplantation
The microvasculature in the pancreatic islet is highly specialized for glucose sensing and
insulin secretion. Although pancreatic islet transplantation is a potentially life-changing …
insulin secretion. Although pancreatic islet transplantation is a potentially life-changing …
Nanotechnology in cell replacement therapies for type 1 diabetes
Islet transplantation is a promising long-term, compliance-free, complication-preventing
treatment for type 1 diabetes. However, islet transplantation is currently limited to a narrow …
treatment for type 1 diabetes. However, islet transplantation is currently limited to a narrow …
Engineering superstable islets-laden chitosan microgels with carboxymethyl cellulose coating for long-term blood glucose regulation in vivo
H Li, W He, Q Feng, J Chen, X Xu, C Lv, C Zhu… - Carbohydrate …, 2024 - Elsevier
Islet transplantation to restore endogenous insulin secretion is a promising therapy for type 1
diabetes in clinic. However, host immune rejection seriously limits the survival of …
diabetes in clinic. However, host immune rejection seriously limits the survival of …
A collagen based cryogel bioscaffold that generates oxygen for islet transplantation
The aim of this article is to develop, characterize, and test a novel 3D bioscaffold matrix that
can accommodate pancreatic islets and provide them with a continuous, controlled, and …
can accommodate pancreatic islets and provide them with a continuous, controlled, and …
The emerging field of pancreatic tissue engineering: A systematic review and evidence map of scaffold materials and scaffolding techniques for insulin-secreting cells
GA Salg, NA Giese, M Schenk… - Journal of tissue …, 2019 - journals.sagepub.com
A bioartificial endocrine pancreas is proposed as a future alternative to current treatment
options. Patients with insulin-secretion deficiency might benefit. This is the first systematic …
options. Patients with insulin-secretion deficiency might benefit. This is the first systematic …
[HTML][HTML] 3D alveolar in vitro model based on epithelialized biomimetically curved culture membranes
There is increasing evidence that surface curvature at a near-cell-scale influences cell
behaviour. Epithelial or endothelial cells lining small acinar or tubular body lumens, as those …
behaviour. Epithelial or endothelial cells lining small acinar or tubular body lumens, as those …
Prevascularized retrievable hybrid implant to enhance function of subcutaneous encapsulated islets
Replacement of pancreatic β-cells is one of the most promising treatment options for
treatment of type 1 diabetes (T1D), even though, toxic immunosuppressive drugs are …
treatment of type 1 diabetes (T1D), even though, toxic immunosuppressive drugs are …
Engineering metabolism to modulate immunity
Metabolic programming and reprogramming have emerged as pivotal mechanisms for
altering immune cell function. Thus, immunometabolism has become an attractive target …
altering immune cell function. Thus, immunometabolism has become an attractive target …
Localized drug delivery graphene bioscaffolds for cotransplantation of islets and mesenchymal stem cells
In the present work, we developed, characterized, and tested an implantable graphene
bioscaffold which elutes dexamethasone (Dex) that can accommodate islets and adipose …
bioscaffold which elutes dexamethasone (Dex) that can accommodate islets and adipose …
Injectable 3D Porous Micro‐Scaffolds with a Bio‐Engine for Cell Transplantation and Tissue Regeneration
Z Luo, J Pan, Y Sun, S Zhang, Y Yang… - Advanced Functional …, 2018 - Wiley Online Library
Bio‐scaffolds designed to mimic endogenous niches have been used extensively in stem
cell therapy and tissue regeneration. However, limited entry of nutrients and cells inside the …
cell therapy and tissue regeneration. However, limited entry of nutrients and cells inside the …