The ubiquitin-proteasome system (UPS) is an essential protein quality controller for
regulating protein homeostasis and autophagy. Ubiquitination is a protein modification …

Musculoskeletal health is directly linked to independence and longevity, but disease and
aging impairs muscle mass and health. Complete repair after a pathological or physiological …

Skeletal muscle is a structurally and functionally remarkable tissue composed of
multinucleated post‐mitotic muscle fibres. These fibres are filled with an exquisite, near …

Mesenchymal stromal cells (MSCs) are multipotent progenitors essential for organogenesis,
tissue homeostasis, regeneration and scar formation. Tissue injury upregulates transforming …

The ubiquitin proteasomal system is a critical regulator of muscle physiology, and impaired
UPS is key in many muscle pathologies. Yet, little is known about the function of …

In recent years, the ubiquitin-proteasome system (UPS) has emerged as an important
regulator of stem cell function. Here we review recent findings indicating that UPS also plays …

Ubiquitination is a posttranslational modification that plays important roles in regulating
protein stability, function, localization, and protein-protein interactions. Proteins are …

In vivo, muscle and neuronal cells are post-mitotic, and their function is predominantly
regulated by proteostasis, a multilayer molecular process that maintains a delicate balance …

Satellite cells (SCs) are tissue-specific stem cells responsible for adult skeletal muscle
regeneration and maintenance. SCs function is critically dependent on two families of …

Mesenchymal stromal cells (MSCs) are multipotent progenitors essential for organogenesis,
tissue homeostasis, regeneration, and scar formation. Tissue injury upregulates TGF-β …