Glutamate excitotoxicity is a hypothesis that states excessive glutamate causes neuronal
dysfunction and degeneration. As glutamate is a major excitatory neurotransmitter in the …

Mammalian Na+/Ca2+ exchangers are members of three branches of a much larger family
of transport proteins [the CaCA (Ca2+/cation antiporter) superfamily] whose main role is to …

Extracellular α‐synuclein (α‐syn) assemblies can be up‐taken by neurons; however, their
interaction with the plasma membrane and proteins has not been studied specifically. Here …

The interplay among reactive oxygen species (ROS) formation, elevated intracellular
calcium concentration and mitochondrial demise is a recurring theme in research focusing …

A body of evidence suggests that the mechanisms of excitotoxic neuronal damage evoked
by excessive or prolonged activation of the excitatory amino acid receptors may be involved …

Na+–Ca2+ exchanger (NCX) controls cytosolic Ca2+ and Na+ concentrations ([Ca2+] i and
[Na+] i) in eukaryotic cells. Here we investigated by immunocytochemistry the cellular and …

The midgut of hematophagous insects is the initial site of infection by arthropod-borne
viruses (arboviruses) and plays a crucial role in vector competence. To further understand …

The specific role played by NCX1, NCX2, and NCX3, the three isoforms of the Na+/Ca2+
exchanger (NCX), has been explored during hypoxic conditions in BHK cells stably …

Glutamate excitotoxicity, a major component of many neurodegenerative disorders, is
characterized by excessive calcium influx selectively through NMDARs. However, there is a …

Plasma membrane Na+/Ca 2+-exchangers play a predominant role in Ca 2+ extrusion in
brain. Neurons express several different Na+/Ca 2+-exchangers belonging to both the K+ …