The nucleoplasm is not homogenous; it consists of many types of nuclear bodies, also
known as nuclear domains or nuclear subcompartments. These self-organizing structures …

Many neurogenetic disorders are caused by the mutation of ubiquitously expressed genes.
One such disorder, spinal muscular atrophy, is caused by loss or mutation of the survival …

Spinal muscular atrophy (SMA), a common autosomal recessive form of motoneuron
disease in infants and young adults, is caused by mutations in the survival motoneuron 1 …

Abstract The multifunctional Survival Motor Neuron (SMN) protein is required for the survival
of all organisms of the animal kingdom. SMN impacts various aspects of RNA metabolism …

Spinal muscular atrophy (SMA) is an autosomal recessive disorder in humans which results
in the loss of motor neurons. It is caused by reduced levels of the survival motor neuron …

Spinal muscular atrophy (SMA) is an autosomal recessive disorder characterized by a loss
of α motoneurons in the spinal cord. SMA is caused by low levels of the ubiquitously …

This review surveys what is known about the structure and function of the subnuclear
domains called Cajal bodies (CBs). The major focus is on CBs in mammalian cells but we …

Spinal muscular atrophy is a common, often lethal, neurodegenerative disease that results
from low levels of, or loss-of-function mutations in, the SMN (survival of motor neurons) …

Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by homozygous
mutations or deletions in the survival of motor neuron (SMN1) gene, encoding the …

Spinal muscular atrophy (SMA) is an inherited motor neuron disease caused by mutation of
the telomeric copy of the survival motor neuron gene (SMN1). Although a centromeric copy …