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Chemical inhibition of sterol biosynthesis
Cholesterol is an essential molecule of life, and its synthesis can be inhibited by both
genetic and nongenetic mechanisms. Hundreds of chemicals that we are exposed to in our …
genetic and nongenetic mechanisms. Hundreds of chemicals that we are exposed to in our …
No bridge between us: EXAFS and computations confirm two distant iron ions comprise the active site of alkane monooxygenase (AlkB)
CR Reinhardt, JA Lee, L Hendricks… - Journal of the …, 2025 - ACS Publications
Alkane monooxygenase (AlkB) is the dominant enzyme that catalyzes the oxidation of liquid
alkanes in the environment. Two recent structural models derived from cryo-electron …
alkanes in the environment. Two recent structural models derived from cryo-electron …
Erg251 has complex and pleiotropic effects on sterol composition, azole susceptibility, filamentation, and stress response phenotypes
X Zhou, A Hilk, NV Solis, N Pereira De Sa… - PLoS …, 2024 - journals.plos.org
Ergosterol is essential for fungal cell membrane integrity and growth, and numerous
antifungal drugs target ergosterol. Inactivation or modification of ergosterol biosynthetic …
antifungal drugs target ergosterol. Inactivation or modification of ergosterol biosynthetic …
AaRgs2 regulates growth and virulence of Alternaria alternata by maintaining reactive oxygen species (ROS) balance
Y Nan, M Zhang, Y Yang, R Li, Q Jiang, X Wang… - Postharvest Biology and …, 2025 - Elsevier
Regulator of G protein AaRgs2 plays an important role in vegetative growth, melanin
production and secretion, stress response and appressorium-like formation in Alternaria …
production and secretion, stress response and appressorium-like formation in Alternaria …
Erg251 has complex and pleiotropic effects on azole susceptibility, filamentation, and stress response phenotypes
Ergosterol is essential for fungal cell membrane integrity and growth, and numerous
antifungal drugs target ergosterol. Inactivation or modification of ergosterol biosynthetic …
antifungal drugs target ergosterol. Inactivation or modification of ergosterol biosynthetic …
Integrated metabolomics and transcriptomics reveal metabolic alterations of Ophiocordyceps sinensis from different geographical regions
J Zhang, W Zhang, H Zhang, W Zhang, C He, H Yu… - Food Bioscience, 2024 - Elsevier
Ophiocordyceps sinensis is a prized edible and medicinal fungus due to its high nutritional
value and broad pharmacological properties. The quality of O. sinensis from Nagqu in Tibet …
value and broad pharmacological properties. The quality of O. sinensis from Nagqu in Tibet …
[HTML][HTML] Evaluation of Antifungal Selective Toxicity Using Candida glabrata ERG25 and Human SC4MOL Knock-In Strains
K Nakano, M Okamoto, A Takahashi-Nakaguchi… - Journal of Fungi, 2023 - mdpi.com
With only four classes of antifungal drugs available for the treatment of invasive systemic
fungal infections, the number of resistant fungi is increasing, highlighting the urgent need for …
fungal infections, the number of resistant fungi is increasing, highlighting the urgent need for …
Evaluating the Impact of Antifungal Drugs on Human Health and Exploring Alternative Treatments.
D MANDAL - Oriental Journal of Chemistry, 2024 - search.ebscohost.com
Fungi occurred naturally like Candida yeast, in the human body. It may grow on skin, inside
the digestive system and vagina. Antifungal drugs are used to kill or stop this fungal growth …
the digestive system and vagina. Antifungal drugs are used to kill or stop this fungal growth …
No Bridge Between Us: Two Distant Iron Ions Comprise the Active Site of Alkane Monooxygenase (AlkB)
C Reinhardt, J Lee, L Hendricks, T Green… - 2024 - chemrxiv.org
Alkane monooxygenase (AlkB) is the dominant enzyme that catalyzes the oxidation of liquid
alkanes in the environment. Two recent structural models derived from cryo-electron …
alkanes in the environment. Two recent structural models derived from cryo-electron …