Although modern techniques such as two-photon microscopy can now provide cellular-level
three-dimensional imaging of the intact living brain, the speed and fields of view of these …

Connectivity map** based on resting-state activity in mice has revealed functional motifs
of correlated activity. However, the rules by which motifs organize into larger functional …

While seizure activity may be electrographically widespread, increasing evidence has
suggested that ictal discharges may in fact represent travelling waves propagated from a …

Focal epilepsy involves excessive cortical activity that propagates both locally and distally.
Does this propagation follow the same routes as normal cortical activity? We …

Neuroimaging techniques applied to a variety of organisms—from zebrafish, to rodents to
humans—can offer valuable insights into neuronal network properties and their dysfunction …

Monitoring astrocytic Ca2+ activity is essential to understand the physiological and
pathological roles of astrocytes in the brain. However, previous commonly used methods for …

Recently there has been an increasing trend to use deep learning frameworks for both 2D
consumer images and for 3D medical images. However, there has been little effort to use …

Epilepsy is a multi-etiological brain dysfunction syndrome. Hippocampal neuronal damage
induced by seizures may be one of the causes leading to cognitive impairment, but the …

Prolonged exposure to abnormally high calcium concentrations is thought to be a core
mechanism underlying hippocampal damage in epileptic patients; however, no prior study …

The epileptic brain is distinguished by spontaneous seizures and interictal epileptiform
discharges (IEDs). Basic patterns of mesoscale brain activity outside of seizures and IEDs …