Tissue macrophages rapidly recognize and engulf apoptotic cells. These events require the
display of so-called eat-me signals on the apoptotic cell surface, the most fundamental of …

The phagocytic clearance of dying cells in a tissue is a highly orchestrated series of
intercellular events coordinated by a complex signaling network. Recent data from genetic …

The evolutionary origin of metazoan cell types such as neurons and muscles is not known.
Using whole-body single-cell RNA sequencing in a sponge, an animal without nervous …

Microglia are the resident brain macrophages and they have been traditionally studied as
orchestrators of the brain inflammatory response during infections and disease. In addition …

Programmed cell death is a distinct genetic and biochemical pathway essential to
metazoans. An intact death pathway is required for successful embryonic development and …

Clearance of apoptotic cells is the final stage of programmed cell death. Uncleared corpses
can become secondarily necrotic, promoting inflammation and autoimmunity. Remarkably …

The'invisible hand'is a term originally coined by Adam Smith in The Theory of Moral
Sentiments to describe the forces of self-interest, competition and supply and demand that …

Rho GTPases control signal transduction pathways that link cell surface receptors to a
variety of intracellular responses. They are best known as regulators of the actin …

Focal adhesions lie at the convergence of integrin adhesion, signaling and the actin
cytoskeleton. Cells modify focal adhesions in response to changes in the molecular …

Everyday we turnover billions of cells. The quick, efficient, and immunologically silent
disposal of the dying cells requires a coordinated orchestration of multiple steps, through …