'Big data'in mental health research: current status and emerging possibilities

R Stewart, K Davis - Social psychiatry and psychiatric epidemiology, 2016 - Springer
Purpose 'Big data'are accumulating in a multitude of domains and offer novel opportunities
for research. The role of these resources in mental health investigations remains relatively …

[HTML][HTML] Physiological and genetic adaptations to diving in sea nomads

MA Ilardo, I Moltke, TS Korneliussen, J Cheng, AJ Stern… - Cell, 2018 - cell.com
Understanding the physiology and genetics of human hypoxia tolerance has important
medical implications, but this phenomenon has thus far only been investigated in high …

Population structure of Han Chinese in the modern Taiwanese population based on 10,000 participants in the Taiwan Biobank project

CH Chen, JH Yang, CWK Chiang… - Human molecular …, 2016 - academic.oup.com
Abstract The Taiwan Biobank (TWB) aims to build a nationwide research database that
integrates genomic/epigenomic profiles, lifestyle patterns, dietary habits, environmental …

Single nucleotide polymorphisms in Mycobacterium tuberculosis and the need for a curated database

D Stucki, S Gagneux - Tuberculosis, 2013 - Elsevier
Recent advances in DNA sequencing have led to the discovery of thousands of single
nucleotide polymorphisms (SNPs) in clinical isolates of Mycobacterium tuberculosis …

Kaviar: an accessible system for testing SNV novelty

G Glusman, J Caballero, DE Mauldin, L Hood… - …, 2011 - academic.oup.com
With the rapidly expanding availability of data from personal genomes, exomes and
transcriptomes, medical researchers will frequently need to test whether observed genomic …

Genomic landscape of human diversity across Madagascar

D Pierron, M Heiske… - Proceedings of the …, 2017 - National Acad Sciences
Although situated∼ 400 km from the east coast of Africa, Madagascar exhibits cultural,
linguistic, and genetic traits from both Southeast Asia and Eastern Africa. The settlement …

Resolving the ancestry of Austronesian-speaking populations

PA Soares, JA Trejaut, T Rito, B Cavadas, C Hill… - Human genetics, 2016 - Springer
There are two very different interpretations of the prehistory of Island Southeast Asia (ISEA),
with genetic evidence invoked in support of both. The “out-of-Taiwan” model proposes a …

Enlightening discriminative network functional modules behind Principal Component Analysis separation in differential-omic science studies

S Ciucci, Y Ge, C Durán, A Palladini… - Scientific reports, 2017 - nature.com
Omic science is rapidly growing and one of the most employed techniques to explore
differential patterns in omic datasets is principal component analysis (PCA). However, a …

Nonparametric approaches for population structure analysis

L Alhusain, AM Hafez - Human genomics, 2018 - Springer
The analysis of population structure has many applications in medical and population
genetic research. Such analysis is used to provide clear insight into the underlying genetic …

Genome-wide SNP analysis reveals population structure and demographic history of the Ryukyu islanders in the southern part of the Japanese archipelago

T Sato, S Nakagome, C Watanabe… - Molecular Biology …, 2014 - academic.oup.com
Abstract The Ryukyu Islands are located to the southwest of the Japanese archipelago.
Archaeological evidence has revealed the existence of prehistoric cultural differentiation …