Type I interferon in chronic virus infection and cancer
Type I interferons (IFN-Is) are emerging as key drivers of inflammation and
immunosuppression in chronic infection. Control of these infections requires IFN-I signaling; …
immunosuppression in chronic infection. Control of these infections requires IFN-I signaling; …
High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
MT Lotze, KJ Tracey - Nature Reviews Immunology, 2005 - nature.com
High-mobility group box 1 protein (HMGB1), which previously was thought to function only
as a nuclear factor that enhances transcription, was recently discovered to be a crucial …
as a nuclear factor that enhances transcription, was recently discovered to be a crucial …
Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria
W Wang, H Xu, Q Ye, F Tao, I Wheeldon… - Nature biomedical …, 2022 - nature.com
Because the tumour microenvironment is typically immunosuppressive, the release of
tumour antigens mediated by radiotherapy or chemotherapy does not sufficiently activate …
tumour antigens mediated by radiotherapy or chemotherapy does not sufficiently activate …
Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity
Autoimmune connective tissue diseases arise in a stepwise fashion from asymptomatic
preclinical autoimmunity. Type I interferons have a crucial role in the progression to …
preclinical autoimmunity. Type I interferons have a crucial role in the progression to …
IDO expression by dendritic cells: tolerance and tryptophan catabolism
AL Mellor, DH Munn - Nature Reviews Immunology, 2004 - nature.com
Abstract Indoleamine 2, 3-dioxygenase (IDO) is an enzyme that degrades the essential
amino acid tryptophan. The concept that cells expressing IDO can suppress T-cell …
amino acid tryptophan. The concept that cells expressing IDO can suppress T-cell …
Immunosuppressive strategies that are mediated by tumor cells
Despite major advances in understanding the mechanisms leading to tumor immunity, a
number of obstacles hinder the successful translation of mechanistic insights into effective …
number of obstacles hinder the successful translation of mechanistic insights into effective …
Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy
Tumour-associated macrophages (TAM) represent the major inflammatory component of the
stroma of many tumours, and can affect different aspects of the neoplastic tissue. Many …
stroma of many tumours, and can affect different aspects of the neoplastic tissue. Many …
IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors
YJ Liu - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract Type 1 interferon-(α, β, ω)-producing cells (IPCs), also known as plasmacytoid
dendritic cell precursors (pDCs), represent 0.2%–0.8% of peripheral blood mononuclear …
dendritic cell precursors (pDCs), represent 0.2%–0.8% of peripheral blood mononuclear …
Plasmacytoid dendritic cells in immunity
Human and mouse plasmacytoid dendritic cells have been shown to correspond to a
specialized cell population that produces large amounts of type I interferons in response to …
specialized cell population that produces large amounts of type I interferons in response to …
The role of CXCR3 and its chemokine ligands in skin disease and cancer
Chemokines and their receptors play an important role in the recruitment, activation and
differentiation of immune cells. The chemokine receptor, CXCR3, and its ligands, CXCL9 …
differentiation of immune cells. The chemokine receptor, CXCR3, and its ligands, CXCL9 …