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Third-generation sequencing in the clinical laboratory: exploring the advantages and challenges of nanopore sequencing
Metagenomic sequencing for infectious disease diagnostics is an important tool that holds
promise for use in the clinical laboratory. Challenges for implementation so far include high …
promise for use in the clinical laboratory. Challenges for implementation so far include high …
Clinical use of whole genome sequencing for Mycobacterium tuberculosis
Drug-resistant tuberculosis (TB) remains a major challenge to global health and to
healthcare in the UK. In 2014, a total of 6,520 cases of TB were recorded in England, of …
healthcare in the UK. In 2014, a total of 6,520 cases of TB were recorded in England, of …
The Oxford Nanopore MinION: delivery of nanopore sequencing to the genomics community
Nanopore DNA strand sequencing has emerged as a competitive, portable technology.
Reads exceeding 150 kilobases have been achieved, as have in-field detection and …
Reads exceeding 150 kilobases have been achieved, as have in-field detection and …
Long-read metagenomic sequencing reveals shifts in associations of antibiotic resistance genes with mobile genetic elements from sewage to activated sludge
Background There is concern that the microbially rich activated sludge environment of
wastewater treatment plants (WWTPs) may contribute to the dissemination of antibiotic …
wastewater treatment plants (WWTPs) may contribute to the dissemination of antibiotic …
Whole-genome sequencing of bacterial pathogens: the future of nosocomial outbreak analysis
Outbreaks of multidrug-resistant bacteria present a frequent threat to vulnerable patient
populations in hospitals around the world. Intensive care unit (ICU) patients are particularly …
populations in hospitals around the world. Intensive care unit (ICU) patients are particularly …
[HTML][HTML] Current and future technologies for the detection of antibiotic-resistant bacteria
Antibiotic resistance is a global public health concern, posing a significant threat to the
effectiveness of antibiotics in treating bacterial infections. The accurate and timely detection …
effectiveness of antibiotics in treating bacterial infections. The accurate and timely detection …
A review on the applications of next generation sequencing technologies as applied to food-related microbiome studies
Y Cao, S Fanning, S Proos, K Jordan… - Frontiers in …, 2017 - frontiersin.org
The development of next generation sequencing (NGS) techniques has enabled
researchers to study and understand the world of microorganisms from broader and deeper …
researchers to study and understand the world of microorganisms from broader and deeper …
Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis
The rise of antibiotic-resistant bacteria has led to an urgent need for rapid detection of drug
resistance in clinical samples, and improvements in global surveillance. Here we show how …
resistance in clinical samples, and improvements in global surveillance. Here we show how …
Rapid methods for antimicrobial resistance diagnostics
Antimicrobial resistance (AMR) is one of the most challenging threats in public health; thus,
there is a growing demand for methods and technologies that enable rapid antimicrobial …
there is a growing demand for methods and technologies that enable rapid antimicrobial …
Twenty years of bacterial genome sequencing
Twenty years ago, the publication of the first bacterial genome sequence, from Haemophilus
influenzae, shook the world of bacteriology. In this Timeline, we review the first two decades …
influenzae, shook the world of bacteriology. In this Timeline, we review the first two decades …