The intramembrane protease γ-secretase is a hetero-tetrameric protein complex with
presenilin as the catalytic subunit and cleaves its membrane protein substrates within their …

Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

Abstract γ-Secretase is a fascinating, multi-subunit, intramembrane cleaving protease that is
now being considered as a therapeutic target for a number of diseases. Potent, orally …

Degeneration of basal forebrain cholinergic neurons (BFCNs) contributes to cognitive
dysfunction in Alzheimer's disease (AD) and Down's syndrome (DS). We used Ts65Dn and …

Alzheimer´ s disease (AD) is a devastating neurodegenerative disease of the elderly
population. Genetic evidence strongly suggests that aberrant generation and/or clearance of …

Recent findings suggest that hypercholesterolemia may contribute to the onset of
Alzheimer's disease‐like dementia but the underlying mechanisms remain unknown. In this …

We investigated the therapeutic efficacy of the selective M1 muscarinic agonist AF267B in
the 3xTg-AD model of Alzheimer disease. AF267B administration rescued the cognitive …

Buoyant membrane fractions containing presenilin 1 (PS1), an essential component of the γ-
secretase complex, and APP CTFβ, a γ-secretase substrate, can be isolated from cultured …

Results PS‐mediated γ‐secretase cleavage results not only in the generation of soluble Aβ
but also in the generation of a βAPP C‐terminal fragment (CTFγ) representing the …

Defining the molecular mechanisms that integrate diverse signaling pathways at the level of
gene transcription remains a central issue in biology. Here, we demonstrate that interleukin …