[HTML][HTML] Personalizing busulfan-based conditioning: considerations from the american society for blood and marrow transplantation practice guidelines committee

J Palmer, JS McCune, MA Perales, D Marks… - Biology of Blood and …, 2016 - Elsevier
Abstract The Practice Guidelines Committee of the American Society of Blood or Marrow
Transplantation (ASBMT) sought to develop an evidence-based review about personalizing …

A practical guide to therapeutic drug monitoring in busulfan: recommendations from the Pharmacist Committee of the European Society for Blood and Marrow …

V Domingos, K Nezvalova-Henriksen… - Bone Marrow …, 2024 - nature.com
Busulfan (Bu) is an important component of many conditioning regimens for allogeneic
hematopoietic cell transplantation. The therapeutic window of Bu is well characterized, with …

[HTML][HTML] Once daily iv busulfan and fludarabine (iv Bu-Flu) compares favorably with iv busulfan and cyclophosphamide (iv BuCy2) as pretransplant conditioning …

BS Andersson, M de Lima, PF Thall, X Wang… - Biology of Blood and …, 2008 - Elsevier
We postulated that fludarabine (Flu) instead of cyclophosphamide (Cy) combined with iv
busulfan (Bu) as preconditioning for allogeneic hematopoietic stem cell transplantation …

Therapeutic drug monitoring of busulfan in transplantation

JA Russell, SB Kangarloo - Current pharmaceutical design, 2008 - ingentaconnect.com
Busulfan is the only agent used in myeloablative regimens for hematopoietic stem cell
transplantation for which therapeutic drug monitoring (TDM) has been widely used. Studies …

[HTML][HTML] Pharmacokinetic disposition and clinical outcomes in infants and children receiving intravenous busulfan for allogeneic hematopoietic stem cell …

T Schechter, Y Finkelstein, J Doyle, Z Verjee… - Biology of Blood and …, 2007 - Elsevier
We conducted a retrospective pharmacokinetic analysis of iv busulfan in children
undergoing hematopoietic stem cell transplantation (HSCT) and describe its relation to …

Once-daily iv BU-based conditioning regimen before allogeneic hematopoietic SCT: a study of influence of GST gene polymorphisms on BU pharmacokinetics and …

J Yin, Y **ao, H Zheng, YC Zhang - Bone marrow transplantation, 2015 - nature.com
Iv BU has been proven to have better bioavailability, reliable systemic drug exposure with
more predictable blood levels and lower toxicity than oral BU when used as part of …

Reduced‐toxicity conditioning with fludarabine, once‐daily intravenous busulfan, and antithymocyte globulins prior to allogeneic stem cell transplantation: results of a …

M Mohty, F Malard, D Blaise, N Milpied, S Furst… - Cancer, 2015 - Wiley Online Library
BACKGROUND The optimal intensity of myeloablation delivered as part of a reduced‐
intensity/toxicity conditioning (RIC/RTC) regimen to decrease the recurrence rate, without …

Busulphan in blood and marrow transplantation: dose, route, frequency and role of therapeutic drug monitoring

C Ellen Nath, P John Shaw - Current clinical pharmacology, 2007 - ingentaconnect.com
Busulphan (Bu) is an alkylating agent that, when combined with agents such as
cyclophosphamide (Cy), ablates the bone marrow prior to blood or marrow transplantation …

Variability in the pharmacokinetics of intravenous busulphan given as a single daily dose to paediatric blood or marrow transplant recipients

CE Nath, JW Earl, N Pati, K Stephen… - British journal of …, 2008 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• The pharmacokinetics of oral
busulphan given four times daily has been extensively studied.• Large inter‐and …

Individualized busulfan dosing improves outcomes compared to fixed‐dose administration in pre‐transplant minimal residual disease‐positive acute myeloid …

E Klyuchnikov, C Langebrake… - European journal of …, 2023 - Wiley Online Library
Pre‐transplant minimal residual disease (MRD) impacts negatively on post‐transplant
relapse risk in acute myeloid leukemia (AML). Therapeutic drug monitoring by calculating …