The stomach is traditionally regarded as a hollow muscular sac that initiates the second
phase of digestion. Yet this simple view ignores the fact that it is the most sophisticated …

Obesity is a global epidemic, placing socioeconomic strain on public healthcare systems,
especially within the so-called Western countries, such as Australia, United States, United …

Aims Netazepide, a gastrin/cholecystokinin 2 receptor antagonist, once daily for 12 weeks
reduced the number of tumours and size of the largest one in 16 patients with autoimmune …

Little is known about the role of tumor necrosis factor-alpha (TNF-α), plasminogen activator
inhibitor-1 (PAI-1), and inducible nitric oxide synthase (iNOS) in the gastric ulcer and the …

Introduction Autoimmune chronic atrophic gastritis (CAG) causes hypochlorhydria and
hypergastrinaemia, which can lead to enterochromaffin-like (ECL) cell hyperplasia and …

The existence of the hormone gastrin in the distal stomach (antrum) has been known for
almost 110 years, and the physiological function of this amidated peptide in regulating …

Objective. Gastric carcinoids (neuroendocrine tumors) arise from enterochromaffin-like cells
in the gastric mucosa. Most are caused by hypergastrinemia. The objectives were to …

Background and Aims Elevated circulating concentrations of the hormone gastrin contribute
to the development of gastric adenocarcinoma and types-1 and 2 gastric neuroendocrine …

Background The peptide hormone gastrin exerts a growth-promoting effect in both normal
and malignant gastrointestinal tissue. Gastrin mediates its effect via the cholecystokinin 2 …

Salt-inducible kinase 1 (SIK1/Snf1lk) belongs to the AMP-activated protein kinase (AMPK)
family of kinases, all of which play major roles in regulating metabolism and cell growth …