This ENETS guidance paper aims to provide practical advice to clinicians for the diagnosis,
treatment and follow‐up of functioning syndromes in pancreatic neuroendocrine tumours …

'Pituitary tumours' is an umbrella term for various tumours originating from different regions
of the hypothalamic–pituitary system. The vast majority of pituitary tumours are pituitary …

Multiple endocrine neoplasia 4 (MEN4) is a rare multiglandular endocrine neoplasia
syndrome clinically hallmarked by primary hyperparathyroidism (PHPT), pituitary adenoma …

Objective Multiple endocrine neoplasia type 4 (MEN4) is caused by a CDKN1B germline
mutation first described in 2006. Its estimated prevalence is less than one per million. The …

Hyperparathyroidism is a common endocrine disorder characterized by elevated levels of
parathyroid hormone and hypercalcemia and is divided into 3 types: primary, secondary …

Prolactinomas are the commonest form of pituitary neuroendocrine tumor (PitNET),
representing approximately half of such tumors. Dopamine agonists (DAs) have traditionally …

Abstract Context Germline CDKN1B variants predispose patients to multiple endocrine
neoplasia type 4 (MEN4), a rare MEN1-like syndrome, with< 100 reported cases since its …

Familial endocrine tumor syndromes are continuously expanding owing to the growing role
of genetic testing in routine clinical practice. Pathologists are usually the first on the clinical …

The co-occurrence of primary hyperparathyroidism (PHPT) and pituitary adenomas (PAs) is
often indicative of underlying genetic syndromes such as Multiple Endocrine Neoplasia type …

Context CHEK2 is a cell cycle checkpoint regulator gene with a long-established role as a
clinically relevant, moderate risk breast cancer predisposition gene, with greater risk …