Heterotrimeric G protein-coupled receptors (GPCRs) comprise the largest receptor family in
mammals and are responsible for the regulation of most physiological functions. Besides …

Five canonical tastes, bitter, sweet, umami (amino acid), salty, and sour (acid), are detected
by animals as diverse as fruit flies and humans, consistent with a near-universal drive to …

Taste sensing is a sophisticated chemosensory process, and bitter taste perception is
mediated by type 2 taste receptors (TAS2Rs), or class TG protein–coupled receptors …

One key to animal survival is the detection and avoidance of potentially harmful compounds
by their bitter taste. Variable numbers of taste 2 receptor genes expressed in the gustatory …

Scope To avoid ingestion of potentially harmful substances, humans are equipped with
about 25 bitter taste receptor genes (TAS2R) expressed in oral taste cells. Humans exhibit …

Background The human taste experience is the result of five basic taste qualities, namely
sweet, salty, bitter, sour and umami. Sweet, bitter, and umami are mediated by G protein …

Beside the oral cavity, bitter taste receptors are expressed in several non-gustatory tissues.
Whether extra-oral bitter taste receptors function as sensors for endogenous agonists is …

Background The perception of taste is a prime example of complex signal transduction at the
subcellular level, involving an intricate network of molecular machinery, which can be …

Understanding taste is key for optimizing the palatability of seaweeds and other non‐animal‐
based foods rich in protein. The lingual papillae in the mouth hold taste buds with taste …

Human bitter taste receptor TAS2R14 (T2R14) can widely perceive bitterness, which has
always been an issue for people to overcome. This study was aimed at identifying bioactive …