Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers
J Fang, W Islam, H Maeda - Advanced drug delivery reviews, 2020 - Elsevier
The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid
tumors that is related to their particular anatomical and pathophysiological characteristics …
tumors that is related to their particular anatomical and pathophysiological characteristics …
The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect
J Fang, H Nakamura, H Maeda - Advanced drug delivery reviews, 2011 - Elsevier
The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid
tumors related to their anatomical and pathophysiological differences from normal tissues …
tumors related to their anatomical and pathophysiological differences from normal tissues …
Nanodrug delivery systems modulate tumor vessels to increase the enhanced permeability and retention effect
D Huang, L Sun, L Huang, Y Chen - Journal of personalized medicine, 2021 - mdpi.com
The use of nanomedicine for antitumor therapy has been extensively investigated for a long
time. Enhanced permeability and retention (EPR) effect-mediated drug delivery is currently …
time. Enhanced permeability and retention (EPR) effect-mediated drug delivery is currently …
Vascular permeability in cancer and infection as related to macromolecular drug delivery, with emphasis on the EPR effect for tumor-selective drug targeting
H Maeda - Proceedings of the Japan Academy, Series B, 2012 - jstage.jst.go.jp
Tumor and inflammation have many common features. One hallmark of both is enhanced
vascular permeability, which is mediated by various factors including bradykinin, nitric oxide …
vascular permeability, which is mediated by various factors including bradykinin, nitric oxide …
Bioimaging of nitric oxide
T Nagano, T Yoshimura - Chemical reviews, 2002 - ACS Publications
Bioimaging of Nitric Oxide | Chemical Reviews ACS ACS Publications C&EN CAS Find my
institution Log In Chemical Reviews ACS Publications. Most Trusted. Most Cited. Most Read …
institution Log In Chemical Reviews ACS Publications. Most Trusted. Most Cited. Most Read …
The link between infection and cancer: tumor vasculature, free radicals, and drug delivery to tumors via the EPR effect
H Maeda - Cancer science, 2013 - Wiley Online Library
This review focuses primarily on my own research, including pathogenic mechanisms of
microbial infection, vascular permeability in infection and tumors, and effects of nitric oxide …
microbial infection, vascular permeability in infection and tumors, and effects of nitric oxide …
How does blood oxygen level‐dependent (BOLD) contrast correlate with oxygen partial pressure (pO2) inside tumors?
C Baudelet, B Gallez - … in Medicine: An Official Journal of the …, 2002 - Wiley Online Library
Blood oxygen level‐dependent (BOLD) contrast‐based functional MRI (fMRI) has been
reported as a method to assess the evolution of tumor oxygenation after hyperoxic …
reported as a method to assess the evolution of tumor oxygenation after hyperoxic …
Solid tumor physiology and hypoxia-induced chemo/radio-resistance: novel strategy for cancer therapy: nitric oxide donor as a therapeutic enhancer
H Yasuda - Nitric Oxide, 2008 - Elsevier
Hypoxia exists in solid tumor tissues due to abnormal vasculature, vascular insufficiency,
treatment or malignancy related anemia, and low intratumor blood flow. Hypoxic status in …
treatment or malignancy related anemia, and low intratumor blood flow. Hypoxic status in …
Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application
T Seki, J Fang, H Maeda - Cancer science, 2009 - Wiley Online Library
Dose regimens of anticancer agents are usually designed on the basis of the maximum
tolerable drug doses, and toxicity prevents drug usage at higher doses, even though the …
tolerable drug doses, and toxicity prevents drug usage at higher doses, even though the …
Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications
This review paper attempts to provide an overview of the principles and techniques that are
often termed electron paramagnetic resonance (EPR) oximetry. The paper discusses the …
often termed electron paramagnetic resonance (EPR) oximetry. The paper discusses the …