Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases
The unfolded protein response (UPR) is a homeostatic mechanism by which cells regulate
levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well …
levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well …
The emerging role of zinc transporters in cellular homeostasis and cancer
Zinc is an essential micronutrient that plays a role in the structural or enzymatic functions of
many cellular proteins. Cellular zinc homeostasis involves the opposing action of two …
many cellular proteins. Cellular zinc homeostasis involves the opposing action of two …
[HTML][HTML] Emerging roles of protein disulfide isomerase in cancer
E Lee - BMB reports, 2017 - ncbi.nlm.nih.gov
The protein disulfide isomerase (PDI) family is a group of multifunctional endoplasmic
reticulum (ER) enzymes that mediate the formation of disulfide bonds, catalyze the cysteine …
reticulum (ER) enzymes that mediate the formation of disulfide bonds, catalyze the cysteine …
Protein disulfide isomerase in redox cell signaling and homeostasis
FRM Laurindo, LA Pescatore… - Free Radical Biology and …, 2012 - Elsevier
Thiol proteins may potentially act as redox signaling adaptor proteins, adjusting reactive
oxygen species intermediates to specific signals and redox signals to cell homeostasis. In …
oxygen species intermediates to specific signals and redox signals to cell homeostasis. In …
Novel roles for protein disulphide isomerase in disease states: a double edged sword?
Protein disulphide isomerase (PDI) is a multifunctional redox chaperone of the endoplasmic
reticulum (ER). Since it was first discovered 40 years ago the functions ascribed to PDI have …
reticulum (ER). Since it was first discovered 40 years ago the functions ascribed to PDI have …
The protein disulfide isomerase family: from proteostasis to pathogenesis
In mammalian cells, nearly one-third of proteins are inserted into the endoplasmic reticulum
(ER), where they undergo oxidative folding and chaperoning assisted by approximately 20 …
(ER), where they undergo oxidative folding and chaperoning assisted by approximately 20 …
Potential roles of the endoplasmic reticulum stress pathway in amyotrophic lateral sclerosis
YM Jeon, Y Kwon, S Lee, HJ Kim - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
The endoplasmic reticulum (ER) is a major organelle involved in protein quality control and
cellular homeostasis. ER stress results from structural and functional dysfunction of the …
cellular homeostasis. ER stress results from structural and functional dysfunction of the …
The function of the cellular prion protein in health and disease
The essential role of the cellular prion protein (PrP C) in prion disorders such as Creutzfeldt–
Jakob disease is well documented. Moreover, evidence is accumulating that PrP C may act …
Jakob disease is well documented. Moreover, evidence is accumulating that PrP C may act …
[HTML][HTML] PDIA4: The basic characteristics, functions and its potential connection with cancer
Disulfide bond formation is catalyzed by the protein disulfide Isomerases (PDI) family. This is
a critical step in protein folding which occurs within the endoplasmic reticulum. PDIA4, as a …
a critical step in protein folding which occurs within the endoplasmic reticulum. PDIA4, as a …
Evidence that bank vole PrP is a universal acceptor for prions
Bank voles are uniquely susceptible to a wide range of prion strains isolated from many
different species. To determine if this enhanced susceptibility to interspecies prion …
different species. To determine if this enhanced susceptibility to interspecies prion …