Advances and opportunities in malaria population genomics
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution
Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that
continues to afflict hundreds of millions of people every year. Infections with malaria …
continues to afflict hundreds of millions of people every year. Infections with malaria …
Antimalarial drug resistance and implications for the WHO global technical strategy
Abstract Purpose of Review Five years have passed since the World Health Organization
released its Global Technical Strategy for Malaria (GTS). In that time, progress against …
released its Global Technical Strategy for Malaria (GTS). In that time, progress against …
Resolving the cause of recurrent Plasmodium vivax malaria probabilistically
Relapses arising from dormant liver-stage Plasmodium vivax parasites (hypnozoites) are a
major cause of vivax malaria. However, in endemic areas, a recurrent blood-stage infection …
major cause of vivax malaria. However, in endemic areas, a recurrent blood-stage infection …
The biology of Plasmodium vivax
Plasmodium vivax is the second most prevalent cause of malaria worldwide and the leading
cause of malaria outside of Africa. Although infections are seldom fatal clinical disease can …
cause of malaria outside of Africa. Although infections are seldom fatal clinical disease can …
[HTML][HTML] The molecular basis of antimalarial drug resistance in Plasmodium vivax
Plasmodium vivax is the most geographically widespread cause of human malaria and is
responsible for the majority of cases outside of the African continent. While great progress …
responsible for the majority of cases outside of the African continent. While great progress …
Ape origins of human malaria
PM Sharp, LJ Plenderleith… - Annual review of …, 2020 - annualreviews.org
African apes harbor at least twelve Plasmodium species, some of which have been a source
of human infection. It is now well established that Plasmodium falciparum emerged following …
of human infection. It is now well established that Plasmodium falciparum emerged following …
Distinctive genetic structure and selection patterns in Plasmodium vivax from South Asia and East Africa
Despite the high burden of Plasmodium vivax malaria in South Asian countries, the genetic
diversity of circulating parasite populations is not well described. Determinants of …
diversity of circulating parasite populations is not well described. Determinants of …
[HTML][HTML] A new Plasmodium vivax reference sequence with improved assembly of the subtelomeres reveals an abundance of pir genes
Plasmodium vivax is now the predominant cause of malaria in the Asia-Pacific, South
America and Horn of Africa. Laboratory studies of this species are constrained by the …
America and Horn of Africa. Laboratory studies of this species are constrained by the …
[HTML][HTML] Epidemiology of Plasmodium vivax malaria in India
Historically, malaria in India was predominantly caused by Plasmodium vivax, accounting for
53% of the estimated cases. After the spread of drug-resistant Plasmodium falciparum in the …
53% of the estimated cases. After the spread of drug-resistant Plasmodium falciparum in the …